Background A 12-lipoxygenase in zebra fish (zf12-LOX) was found to be required for normal embryonic development and LOXs are of great interest for targeted drug designing. In this study, we investigate the structural-functional aspects of zf12-LOX in response to calcium. Methods A soluble version of zf12-LOX was created by mutagenesis. Based on multiple sequence alignment, we mutated the putative

This paper presents a search for massive charged long-lived particles produced in pp collisions at s=13 TeV at the LHC using the ATLAS experiment. The data set used corresponds to an integrated luminosity of 3.2 fb-1. Many extensions of the Standard Model predict the existence of massive charged long-lived particles, such as R-hadrons. These massive particles are expected to be produced with a vel

Objective: Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial transcription factor B2 (TFB2M) controls transcription of mitochondrial-encoded genes. However, its precise role in mitochondrial metabolism in pancreati

Corynebacterium sp. (ATCC 21245) is reclassified here as Mycobacterium sp. MS1601 based on 16S rRNA gene and complete-genome sequence analysis. It is able to oxidize branched polyols to corresponding hydroxycarboxylic acids. The total size of the genome sequence was 6,829,132 bp, including one circular chromosome of 6,407,860 bp.

This paper presents a dedicated search for exotic decays of the Higgs boson to a pair of new spin-zero particles, H→ aa, where the particle a decays to b-quarks and has a mass in the range of 20–60 GeV. The search is performed in events where the Higgs boson is produced in association with a W boson, giving rise to a signature of a lepton (electron or muon), missing transverse momentum, and multip

Bullying is a social process where many students not directly involved as bullies or victims are often present as bystanders, who can respond with pro-bullying (assisting and joining the bully or supporting the bully by cheering and laughing), passive bystanding, or defending. Self-determination theory proposed that autonomous motivation reflects a person’s volition, values and interests, and pred

When and where offspring disperse has important implications for the evolutionary emergence and maintenance of group living. In noncooperative breeders, direct benefits of delayed dispersal are relatively limited, suggesting that decisions regarding whether or not to remain in the parental territory are largely driven by the availability of suitable habitat in which to settle. Although there is am

The multi-strange baryon yields in PbPb collisions have been shown to exhibit an enhancement relative to pp reactions. In this work, Ξ and Ω production rates have been measured with the ALICE experiment as a function of transverse momentum, pT, in pPb collisions at a centre-of-mass energy of sNN=5.02 TeV. The results cover the kinematic ranges 0.6 GeV/c

In Swedish, tones on word stems function as predictive cues to upcoming grammatical suffixes. Invalid matching of these linguistic tonal cues to suffixes affects native speakers of Swedish in their linguistic processing (Roll et al., 2010). Planum Temporale (PT) has previously been found to be involved in processing Thai (Xu et al., 2006) and Swedish tones (Roll et al., 2015), and in phonological

The present study explores the interlinkages among the operational variables of a University of Cape Town (UCT) Integrated Fixed Film Activated Sludge (IFAS) membrane bioreactor (MBR) pilot plant. Specifically, dedicated experimental tests were carried out with the final aim to find-out a constitutive relationship among operational costs (OCs), effluent quality index (EQI), effluent fines (EF). Gr

Recent studies have shown that not only managers can increase their subordinates’ work motivation by using an autonomy supportive leadership style; support from co-workers can even be more beneficial. Previous studies have not investigated if the impact of support is the same across different settings. In a vignette study, we manipulated the autonomy support (support vs. thwarting), the source (ma

Projektet ECOSIMP handlar om förutsättningen att implementera ekosystemtjänstbegreppet (EST-begreppet) i kommunerna, och bland annat om hur kommunala tjänstemän och politiker ser på denna utmaning. En stor intervjustudie genomfördes med tjänstemän och politiker i de 7 kommunerna. I en studie av Malmö stad undersöktes också hur ekosystem-relaterade begrepp har integrerats i översiktsplaner och utve

Charged-particle distributions are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV, using a data sample of nearly 9 million events, corresponding to an integrated luminosity of 170 μb-1, recorded by the ATLAS detector during a special Large Hadron Collider fill. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the dependence

Telomerase maintains telomere length and chromosome integrity by adding short tandem repeats of single-stranded DNA to the 3' ends, via reverse transcription of a defined template region of its RNA subunit. To further understand the telomerase elongation mechanism, we studied the primer utilization and extension activity of the telomerase from the budding yeast Naumovozyma castellii (Saccharomyces

Ruthenium clusters containing the chiral binaphthyl-derived mono-phosphiranes [(S)-([1,1'-binaphthalen]-2-yl)phosphirane] (S)-1a, [(R)-(2'-methoxy-1,1'-binaphthyl-2-yl)phosphirane] (R)-1b, and the diphosphirane [2,2'-di(phosphiran-1-yl)-1,1'-binaphthalene] (S)-1c have been synthesized and characterized. The clusters are [(μ-H)4Ru4(CO)11((S)-1a)] (S)-2, [(μ-H)4Ru4(CO)11((R)-1b)] (R)-3, 1,1-[(μ-H)4R

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across anal

FKBP12, a small human enzyme, aids protein folding by catalyzing cis-trans isomerization of peptidyl-prolyl bonds, and is involved in cell signaling pathways, calcium regulation, and the immune response. The underlying molecular mechanisms are not fully understood, but it is well-known that aromatic residues in the active site and neighboring loops are important for substrate binding and catalysis