An insight into the proteome status of today is presented, covering aspects of market values, new scientific literature sources, new technology initiatives and future developments. The authors give a personal view of the importance and the expected progress of microtechnology in proteome research. The background to some of the fundamental analytical technologies where for example, chromatography h

Although drinking patterns in women have received increased attention, few studies have focused on middle-aged women. Drinking patterns were investigated in a population sample of 513 Swedish women aged 50-59, and analysed in relation to social situation, and mental and physical health. The chi-square test was used to analyse differences in proportions. Variables showing significant differences we

INTRODUCTION: The purpose of this prospective study was to compare 3T and 1.5T magnetic resonance angiography (MRA) with digital subtraction angiography (DSA) for the follow-up of endovascular treated intracranial aneurysms to assess the grade of occlusion. MATERIALS AND METHODS: Thirty-seven patients with 41 aneurysms who had undergone endovascular treatment with detachable coils were included. M

AIM: To analyze the association between Helicobacter spp. and some common gut bacteria in patients with cholecystitis. METHODS: A nested-polymerase chain reaction (PCR), specific to 16S rRNA of Helicobacter spp. was performed on paraffin-embedded gallbladder samples of 100 cholecystitis and 102 control cases. The samples were also analyzed for some common gut bacteria by PCR. Positive samples were

Abstract Caveolae are omega-shaped membrane invaginations present in essentially all cell types in the cardiovascular system, and numerous functions have been ascribed to these structures. Caveolae formation depends on caveolins, cholesterol, and PTRF-Cavin (polymerase I and transcript release factor-Cavin). The current review summarizes and critically discusses the cardiovascular phenotypes repor

The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of a fibrin clot. Here we show that C-terminal peptides of thrombin, a key enzyme in the coagulation cascade, constitute a novel class of host defense peptides, released upon proteolysis of thrombin in vitr

Small cell lung carcinoma (SCLC) is an extremely aggressive form of cancer and current treatment protocols are insufficient. SCLC have neuroendocrine characteristics and show phenotypical similarities to the childhood tumor neuroblastoma. As multidrug-resistant neuroblastoma cells are highly sensitive to arsenic trioxide (As2O3) in vitro and in vivo, we here studied the cytotoxic effects of As2O3

One of the largest limitations of standard molecular-mechanics force fields is the neglect of intermolecular polarization. Several attempts to cure this problem have been made, but the results have not always been fully satisfactory. In this paper, we present a quantitative study of the fundamental approximations that underlie polarization models for classical force fields. The induced charge dens

We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.

This volume is a harvest of articles from the first conference in a series on the cognitive neuroscience of language. The first conference focused on the cognitive neuroscience of second language acquisition (henceforth SLA). It brought together experts from as diverse fields as second language acquisition, bilingualism, cognitive neuroscience, and neuroanatomy. The articles and discussion article

Aim:To study the effects of hypobaric pressure chamber exposure on the cochlear frequency selectivity of subjects with monaural, fluctuating, low-frequency hearing loss, such as occurs in Ménière's disease.Methods:We used a hypobaric pressure chamber to create relative underpressure in the ear canal, in order to impose positive pressure gradients on the inner ear. Psychophysical tuning curves, tra

It is widely assumed that there is a natural, prelinguistic conceptual domain of time whose linguistic organization is universally structured via metaphoric mapping from the lexicon and grammar of space and motion. We challenge this assumption on the basis of our research on the Amondawa (Tupi Kawahib) language and culture of Amazonia. Using both observational data and structured field linguistic

Hydropathy is a dominant force in protein folding. Sequence-based hydropathy predictions are widely used, without knowledge about their accuracy and reliability. We investigated the prediction accuracy of 56 hydropathy scales by correlating predicted values with the accessible surface area in known protein structures. Results for different amino acids vary greatly within each scale. We also invest