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Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes

Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex. Enhanced expression with concomitant mislocalization of AQP4 along astrocyte plasma membranes is a hallmark of several neurological conditions. Thus, there is an urgent need t

High-Throughput 3D Phenotyping of Plant Shoot Apical Meristems From Tissue-Resolution Data

Confocal imaging is a well-established method for investigating plant phenotypes on the tissue and organ level. However, many differences are difficult to assess by visual inspection and researchers rely extensively on ad hoc manual quantification techniques and qualitative assessment. Here we present a method for quantitatively phenotyping large samples of plant tissue morphologies using triangul

Progressive and efficient verification for digital signatures

Digital signatures are widely deployed to authenticate the source of incoming information, or to certify data integrity. Common signature verification procedures return a decision (accept/reject) only at the very end of the execution. If interrupted prematurely, however, the verification process cannot infer any meaningful information about the validity of the given signature. We notice that this

Outsourcing MPC Precomputation for Location Privacy

Proximity testing is at the core of sev-eral Location-Based Services (LBS) offered by, e.g., Uber, Facebook, and BlaBlaCar, as it determines closeness to a target. Unfortunately, modern LBS demand not only that clients disclose their locations in plain, but also to trust that the services will not abuse this information. These requirements are unfounded as there are ways to perform proximity testi

MR- safety : Evaluation of compliance with screening routines using a structured screening interview

Background: Magnetic resonance (MR) safety procedures are designed to allow patients, research subjects and personnel to enter the MR-scanner room under controlled conditions and without the risk to be harmed during the examination. Ferromagnetic objects in the MR-environment or inside the human body represent the main safety risks potentially leading to human injuries. Screening for MR-safety ris

Validation of a computational chain from PET Monte Carlo simulations to reconstructed images

The study aimed to create a pipeline from Monte Carlo simulated projections of a Gate PET system to reconstructed images. The PET system was modelled after the GE Discovery MI (DMI) PET/CT, and the simulated projections were reconstructed with the stand-alone reconstruction software CASToR. Attenuation correction, normalisation calibration, random estimation, and scatter estimation for the simulat