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We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with

Isomeric ratios have been measured for high-spin states in Po-198,200,206,208(84), At-208,209,210,211(85), Rn-210,211,212,213,214(86), Fr-208,211,212,213,214(87), Ra-210,211,212,214,215(88), and Ac-215(89) following the projectile fragmentation of a 1 AGeV U-238 beam by a Be-9 target at GSI Helmholtzzentrum fur Schwerionenforschung. The fragments were separated in the fragment separator (FRS) and

The adhesion of water to solid surfaces is characterized by the tendency to balance competing molecule-molecule and molecule-surface interactions. Hydroxyl groups form strong hydrogen bonds to water molecules and are known to substantially influence the wetting behaviour of oxide surfaces, but it is not well-understood how these hydroxyl groups and their distribution on a surface affect the molecu

Sex pheromones are the hallmark of reproductive behavior in moths. Mature females perform the task of mate signaling and release bouquets of odors that attract conspecific males at long range. The pheromone chemistry follows a relatively minimal design but still the combinatorial action of a handful of specialized pheromone production enzymes has resulted in remarkably diverse sexual signals that

This article presents an analysis of a group of converts to Roman Catholicism, hitherto largely unknown in historical research, of Scandinavian origin received in the late 17th and early 18th centuries in Rome by Ospizio dei Convertendi. The article provides an overview of the converts and their motives, examining different factors which influenced the complex conversion process. It suggests that

We verified an active uptake of kleptoplastids in the toxic and bloom-forming dinoflagellates of the genus Dinophysis from its preferred prey, the ciliate Myrionecta rubra, using a quantitative real-time PCR technique. During a 65 d starvation/feeding experiment with Dinophysis caudata, changes in plastid 16S rRNA, plastid autofluorescence and plastid/nuclear DNA ratio through the cell cycle were

Current market trends for industrial automation are the need for customizable production, shorter time to market, and powerful global competitive pressure. Based on these trends two challenges have been identified: 1) flexible production systems and 2) integration and utilization of devices and software. Applications from both process automation, manufacturing, and robotics have been considered.

Traditionally, multi-family houses have been constructed using heavy, homogenous materials like concrete and masonry. But as a consequence of the progress of lightweight building systems during the last decades, it has been questioned whether standardized sound insulation evaluation methods still are appropriate. An extensive measurement template has been applied in a field survey where several vi

Laminar burning velocities of dimethyl carbonate (DMC) + air flames at initial gas mixture temperatures of 298, 318, 338, and 358 K are reported. Nonstretched flames were stabilized on a perforated plate burner at atmospheric pressure, and the laminar burning velocities were determined using the heat flux method. The overall accuracy of the burning velocities was evaluated to be typically better t

The factors that drive partial migration in organisms are not fully understood. Roach (Rutilus rutilus), a freshwater fish, engage in partial migration where parts of populations switch between summer habitats in lakes and winter habitats in connected streams. To test if the partial migration trait is phenotypically plastic or has genetic components, we translocated roach from 2 populations with d

We present in detail a method we recently introduced [Phys. Rev. Lett. 103, 176404 (2009)] to describe finite systems in and out of equilibrium, where the evolution in time is performed via the Kadanoff-Baym equations within many-body perturbation theory. Our systems consist of small, strongly correlated clusters, described by a Hubbard Hamiltonian within the Hartree-Fock, second Born, GW, and T-m

Endotoxemic liver injury is characterized by an initial release of pro-inflammatory cytokines and CXC chemokines, which leads to a recruitment of leukocytes to the liver microvasculature. The mechanisms of leukocyte recruitment are well characterized and comprise on the one hand a mechanical trapping of leukocytes in sinusoids, and on the other hand a multi-step process of leukocyte-endothelial ce

To improve the mechanical characteristics of actively controlled continuous faceplate deformable mirrors in adaptive optics, a strategy for reducing crosstalk between adjacent actuators and for suppressing low-order eigenmodes is proposed. The strategy can be seen as extending Saint-Venant's principle beyond the static case, for small local families of actuators. An analytic model is presented, fr

This paper presents measurement results of electricity use and lighting conditions in individual office rooms located in Lund, Sweden. The aim is to demonstrate the energy saving potential by using different lighting systems and the satisfaction of users. The measurements are carried out in one empty reference room and four fully occupied test rooms equipped with different electric light control s

Acoustic trapping of minute bead amounts against fluid flow allows for easy automation of multiple assay steps, using a convenient aspirate/dispense format. Here, a method based on acoustic trapping that allows sample preparation for immuno-matrix-assisted laser desorption/ionization mass spectrometry using only half a million 2.8 mu m antibody covered beads is presented. The acoustic trapping is

Methods were developed for post-detection and early-warning of defoliation in Scots pine [Pinus silvestris] forests in south-eastern Norway caused by the pine sawfly [Neodiprion sertifer] with the use of multi-temporal MODIS NDVI 16-day composite data. The post-detection method utilizes summer mean values and seasonal angle (showing whether values have increased or decreased during the season) to

In this paper we introduce two new methods for constructing harmonic morphisms from solvable Lie groups. The first method yields global solutions from any simply connected nilpotent Lie group and from any Riemannian symmetric space of non-compact type and rank r ≥ 3. The second method provides us with global solutions from any Damek–Ricci space and many non-compact Riemannian symmetric spaces. We

Popular Abstract in Swedish Idag har patienter med blodcancer (leukemi) eller genetiskt betingade blodsjukdomar (sickelcellanemi etc.) begränsad tillgång till behandlingar som effektivt och riskfritt botar sjukdomstillståndet. Detta arbete inkluderar forskningsresultat ämnade att bidra till utveckling av konceptuellt nya behandlingsmetoder för olika typer av blodsjukdomar. Ett fungerande blodsysteThere is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. The indefinite expansion capacity of PSCs, combined with the possibility of creating these cells from patient-specific

Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition o