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Hen egg-white lysozyme (HEWL) is a widely used model protein in crystallographic studies and its enzymatic mechanism has been extensively investigated for decades. Despite this, the interaction between the reaction intermediate and the catalytic Asp52, as well as the orientation of Asn44 and Asn46 side chains, remain ambiguous. Here, we report the crystal structures of perdeuterated HEWL and D2O b
This review examines the complex interaction between heavy metals and soil microorganisms, focusing on five common heavy metals (HM) (chromium -Cr-, copper -Cu-, nickel -Ni-, lead -Pb-, and zinc -Zn-) in polluted areas worldwide. The systematic review was performed following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The literature selection procedure i
Cellulose and its derivatives are considered sustainable alternatives to non-biodegradable fossil-based plastics. Chemically modified cellulose fibres to dialcohol cellulose (DAC) fibres demonstrated a melt processing window between the glass transition and degradation temperatures which enabled their extrusion by using only water as a temporary plasticizer. With the aim of supporting an industria
Background: High-quality assessment of prostate MRI is fundamental in both clinical practice and screening. There is a lack of national level data on variability in prostate volume measurement and PI-RADS assessment. Methods of quality assurance need to be developed. Methods: All Swedish radiology departments were invited to participate in an external quality assurance of prostate MRI reading. Ten
In this study, laminar burning velocities (LBV) of ammonia in oxygen-enriched air (oxygen content ranging from 30 to 50 vol%) were investigated under various initial temperatures (298, 323, and 348 K) at a pressure of 1 atm, employing the heat flux method. Our measurements reveal substantial disparities with previously published data primarily obtained using the spherical flame method. The reliabi
Introduction: This study aims to evaluate the effects of a novel noise reduction software (INR, Canon Europe, Amsterdam, NL) on image quality (IQ) in Digital Radiography (DR) pelvic phantom images. Methods: In total, 53 pelvic phantom images and 360 technical images of a Contrast Detail Radiography phantom (CDRAD) were collected, including 8 different exposure levels (between 0.8 and 40 mAs at 70
Background: Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT. Objectives: This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive s
What were the effects of having a distinctively African American-sounding name on educational attainment, occupation, income, marital status, and longevity in early 20th century America? How did those effects differ for people based on their phenotypical race/ethnicity? The findings of contemporary research have shown racialized names to be related to negative outcomes such as job interview callba
The virtual reconstruction of the archaeological landscape is a very complex process including in a virtual ecosystem many kinds of data, activities, according to a multidisciplinary approach. This system of relations, interactions and behaviors assumes perceptive, cultural, psychological and relevance. The virtual environment and archaeological structures, as they are today, can be reconstructed
SammanfattningFör induktion av hypertermi i klinisk praxis i LUND utvecklade vi ett 2450 MHz mikrovågssystem, som har använts sedan augusti 1980. 1982 lade vi till frekvensen 915 MHz, och sedan 1986 har vi även 434 MHz tillgängligt. Ett styrsystem baserat på en dator justerar temperaturen i vävnaden genom att alternera temperaturregistrering och mikrovågsstrålning. Konventionella termistorsonder (
Background/Objectives:Catha edulis, also known as Khat, is a stimulant with hepatotoxic properties. Studies reporting laboratory patterns are scarce. The aim was to assess the patterns associated with hepatic dysfunction due to Khat usage. Methods: Patients with liver injury and self-reported Khat consumption presenting to the gastroenterology department at the King Fahad Central Hospital in Jazan
This paper investigates whether executive boards consider firm-specific inefficiencies when they change CEOs in the Swedish electricity distribution sector. Firm-level inefficiencies are calculated using data from all Swedish electricity distributors from 2001 to 2022 and a data envelopment analysis (DEA) approach. DEA has advantages over standard financial key performance indicators since it cont
A Stein-type control function maximum likelihood (CFML) estimator is suggested for the probit model in the presence of endogeneity. This novel estimator combines the probit maximum likelihood and CFML estimators. The asymptotic distribution and risk function for the new estimator is derived. It is demonstrated that, subject to certain conditions of the shrinkage parameter, the asymptotic risk of t
This volume shows how waste in its manifold variety provides an innovative starting point for interrogating twenty-first-century society. Waste in and of itself, along with those who work with it, may suffer from social stigma. As an epistemological point of departure however, waste offers an advantageous platform for social inquiry. Drawing on the contributions from an international team of inter
This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples. This strategy involves using antibodies circulating in plasma to affinity-enrich antigenic proteins in biochemically fractionated pools of bacterial proteins, followed by their identification and quantification using mass spe
Antibodies are critical to the host's immune defense against bacterial pathogens. Understanding the mechanisms of antibody-antigen interactions is essential for developing new targeted immunotherapies. Building computational workflows that can identify where an antibody binds its cognate antigen and deconvoluting the interaction interface in a high-throughput manner are critical for advancing this
In modern high energy physics (HEP) experiments, triggers perform the important task of selecting, in real time, the data to be recorded and saved for physics analyses. As a result, trigger strategies play a key role in extracting relevant information from the vast streams of data produced at facilities like the large hadron collider (LHC). As the energy and luminosity of the collisions increase,
