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Cell-based therapies for Parkinson disease—past insights and future potential NATURE REVIEWS | NEUROLOGY ADVANCE ONLINE PUBLICATION | 1 John van Geest Centre for Brain Repair & Department of Neurology, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK (R.A.B.). Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund U
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease ARTICLE Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease Katarína Tiklová1,2,6, Sara Nolbrant 3,6, Alessandro Fiorenzano3,6, Åsa K. Björklund 4, Yogita Sharma3, Andreas Heuer 3, Linda Gillberg1,2, Deirdre B. Hoban3, Tiago Cardoso
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_nature_com.pdf - 2026-04-25
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation © 2 01 7 N at u re A m er ic a, In c. , p ar t o f S p ri n g er N at u re . A ll ri g h ts r es er ve d . © 2 01 7 N at u re A m er ic a, In c. , p ar t o f S p ri n g er N at u re . A ll ri g h ts r es er ve d . © 2017 Macmillan Publishers Limited, part of Springer
untitled Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases Jenny Nelander, Shane Grealish and Malin Parmar Human foetal brain tissue has been used in experimental and clinical trials to develop cell replacement therapy in neurodegenerative disorders such as Parkinson’s disease and Huntington’s disease. These pioneerin
A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism Marcus Davidssona,1, Gang Wanga,1,2, Patrick Aldrin-Kirka, Tiago Cardosob, Sara Nolbrantb, Morgan Hartnora, Janitha Mudannayakea, Malin Parmarb, and Tom
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas_4.pdf - 2026-04-25
Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior Sara Palma-Tortosaa,1, Daniel Torneroa,b,1 , Marita Grønning Hansena, Emanuela Monnia, Mazin Hajya, Sopiko Kartsivadzea,c, Sibel Aktaya, Oleg Tsupykov
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas_6.pdf - 2026-04-25
Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14–15 September 2015 483Regen. Med. (2016) 11(5), 483–492 ISSN 1746-0751 part of Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop
Small molecules increase direct neural conversion of human fibroblasts 1Scientific RepoRts | 6:38290 | DOI: 10.1038/srep38290 www.nature.com/scientificreports Small molecules increase direct neural conversion of human fibroblasts Ulrich Pfisterer1,2, Fredrik Ek3, Stefan Lang2,4, Shamit Soneji2,4, Roger Olsson3 & Malin Parmar1,2 The generation of human induced neurons (hiNs) via exogenous delivery
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_sci_rep.pdf - 2026-04-25
untitled Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain Maria Pereira, Ulrich Pfisterer, Daniella Rylander, Olof Torper, Shong Lau, Martin Lundblad, Shane Grealish & Malin Parmar Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden. Indu
Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications RESEARCH Open Access Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications Roksana Moraghebi1, Agnete Kirkeby2, Patricia Chaves3, Roger E. Rönn1, Ewa Sitnicka3, Malin Parmar2, Marcus Larsson4*
Transsynaptic tracing and its emerging use to assess graft-reconstructed neural circuits T R AN S L A T I ONA L AND C L I N I C A L R E S E A R CH Transsynaptic tracing and its emerging use to assess graft- reconstructed neural circuits Andrew F. Adler1,2 | Anders Björklund1 | Malin Parmar1,2 1Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuro
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_stem_cells.pdf - 2026-04-25
pnas201006568 1..6 Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors Rohit Sachdevaa, Marie E. Jönssona, Jenny Nelandera, Agnete Kirkebya, Carolina Guibentifa, Bernhard Gentnerb, Luigi Naldinib, Anders Björklunda, Malin Parmara, and Johan Jakobssona,1 aDepartment of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund Uni
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/sachdeva_et_al_pnas_2010.pdf - 2026-04-25
doi:10.1016/S0306-4522(03)00427-5 THE DIFFERENTIATION POTENTIAL OF PRECURSOR CELLS FROM THE MOUSE LATERAL GANGLIONIC EMINENCE IS RESTRICTED BY IN VITRO EXPANSION C. SKOGH,a M. PARMARa AND K. CAMPBELLb* aWallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S-221 84 Lund, Sweden bDivision of Developmental Biology, Children’s Hospital Research Foundation,
THE FANTASTIC FOUR n the retail business, the term G-force is routinely used to promote “hi-tech” products, whether it be racing gear, clothing or watches with uniquely durable qualities. In May of this year, a group of Parkinson’s researchers chose that same name for a global alliance with real technological prowess. As we stand on the threshold of the first cell transplants in Parkinson’s patien
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/the_fantastic_four.pdf - 2026-04-25
