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BackgroundPediatric heart-lung transplantation (pHLTx) remains the only treatment option for children with significant and fixed elevation of pulmonary vascular resistance (PVR) in the setting of uncorrectable end-stage heart disease. We aimed to determine the characteristics, waiting list course and long-term outcomes for children listed for pHLTx within the Scandiatransplant region.MethodsThis w
Background and Objectives – Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, we tested whether clinical criteria for LATE can detect a clinical profile of LATE that is distinct from AD.Methods – In this retrospective examination of a longitudinal memory c
Introduction – Hand-arm vibration syndrome (HAVS) is a chronic disease to vessels and nerves caused by vibrations. In Sweden, the medical check-up for vibrations (MCV) implements the EU surveillance system to detect early cases. No earlier research has shown participation in MCVs, nor why MCVs is avoided. We aimed to improve the understanding on avoidance of MCVs among vibration-exposed workers. M
This study presents an integrated simulation framework that combines agent-based transport modeling with probabilistic load-flow analysis to quantify power system loading of long-haul heavy-duty electrification. The approach is applied to a case study considering fully electrified road freight in the Skåne region in Sweden, using high-resolution transport demand data and the actual power grid mode
Introduction:Exclusive breastfeeding (EB) is globally recommended due to health benefits for women and their infants. Home-based postnatal midwifery care (HBPMC) is a model of care where midwives give in-home care during the first postnatal week. The study objectives were to investigate breastfeeding outcomes at two months after birth, in women and newborns receiving HBPMC, and to identify risk fa
The success of cell therapy for type 1 diabetes (T1D) depends on reliable differentiation of stem cells into functional pancreatic islets. Current protocols produce stem cell-derived islets (SC-islets) that contain non-endocrine cells and show limited maturity. We developed a robust protocol that generates functional SC-islets from all eight tested human pluripotent stem cell (hPSC) lines. Differe
Executives recognize that communication is essential to organizational performance and value creation, yet corporate communication‘s specific contribution to value creation remains difficult to articulate. In this article, I introduce a conceptual framework with practical applications that clarifies how value is formed across the corporate communication management process – from identifying stakeh
Abstract: Before the introduction of prostate MRI, prostate cancer screening relied on prostate-specific antigen (PSA) testing followed by a systematic biopsy. Although this approach reduced prostate cancer mortality in large, randomized screening trials, its net benefit was questionable because of substantial overdiagnosis. In response, more precise screening tools have been developed. Diagnostic
Ambivalence is widely regarded as a source of ontological insecurity and anxiety due to its close association with uncertainty, undecidability, and indeterminacy. While ontological security studies (OSS) has usefully engaged with the concept of ambivalence as an epistemic phenomenon and its manifestations in international politics such as ‘strangers’, almost no attention has been paid to ambivalen
Maintaining low background levels is essential for analytical instruments, such as in supercritical fluid chromatography (SFC) coupled to high-resolution mass spectrometry (HRMS). An approximate tenfold increase of the background was observed in our laboratory when a new CO2 cylinder with a dip tube was installed on a SFCHRMS system. Most analyte peaks were obscured. This study aimed to find the c
The cardiovascular effects of coffee consumption remain debated, particularly regarding early-stage subclinical atherosclerosis. This study investigated the association between coffee intake, genetic predisposition, and the risk of subclinical coronary and carotid atherosclerosis in 24,835 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Coffee intake was assessed via self-re
We report on the shift of energies released during Auger cascades in rare-gas ions, when the ions are not isolated but embedded in a homogeneous cluster. By combining high-resolution electron spectroscopy with multielectron coincidence spectroscopy of small Ar and Xe clusters, we investigate the dependence of Auger electron emission energies on the charge state of the emitting ion in the polarizab
Using Swedish register data for 1993–2022, this paper documents robust spatial heterogeneityin the relationship between transfer generosity and local employment. Transfer reductions areassociated with lower employment among individuals far from the labour market in immigrant-dense neighbourhoods, but with higher employment among individuals with stronger labour-market attachment. This pattern is d
Background: Trigeminal neuralgia is sometimes referred to as the suicide disease, but long-term occurrence of comorbidities and mortality are not well known. The aim of the present study was to investigate whether patients diagnosed with trigeminal neuralgia have an increased risk of morbidity and mortality compared to the general population. Methods: A nationwide, retrospective cohort study was c
The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and characterization. Additionally, current methods for predicting pathoge
This letter analyzes certainty-equivalence adaptive controllers for sampled-data systems through a data-driven Riccati equation. Extending a recent framework for data-driven adaptive control, the proposed formulation provides the sampled-data counterpart that explicitly accounts for intersample behavior via lifted cost representations. Sufficient conditions are derived to guarantee stability and r
The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered regulatory segment whose conserved YENPTY motif mediates transient interactions with multiple adaptor and signaling proteins. How sequence perturbations within this motif modulate its accessibility and interaction potential within a disordered ensemble remains poorly understood. Here, we combine small-angle X-
We describe the solutions to a family of rotationally symmetric second order partial differential equations in the complex plane that arises from a four-dimensional complex Lie algebra whose spanning set generates the algebra from which such generalised harmonic functions derive. We show that every one of these solutions have a canonical series representation and retrieve those obtained in the cas
Objective The basis for protein synthesis is the genetic code. Many of these proteins will affect intermediary metabolites by acting as enzymes, hormones, or by other actions. The aim of the present study was to assess the relationships of a large number of proteins with endogenous metabolites. Methods Plasma protein levels were measured by the proximity extension assay (PEA) and metabolites by ma
