White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK a

The ability of human tissue to reorganize and restore its existing structure underlies tissue homeostasis in the healthy airways, but in disease can persist without normal resolution, leading to an altered airway structure. Eosinophils play a cardinal role in airway remodeling both in health and disease, driving epithelial homeostasis and extracellular matrix turnover. Physiological consequences a

Synonymous (also known as silent) variations are by definition not considered to change the coded protein. Still many variations in this category affect either protein abundance or properties. As this situation is confusing, we have recently introduced systematics for synonymous variations and those that may on the surface look like synonymous, but these may affect the coded protein in various way

Alloys and bimetallic systems have shown many advantages in heterogeneous catalysis, but the details of their catalytic functions are not always known. For instance, the atomic details about surface reconstructions under catalytic reaction conditions, or which phases that are high-active or low-active. Furthermore, the model catalysts studied in laboratories often differ a lot from the industrial

A memetic framework for optimal inverse design is proposed by combining a local gradient-based procedure and a robust global scheme. The procedure is based on method-of-moments matrices and does not demand full inversion of a system matrix. Fundamental bounds are evaluated for all optimized metrics in the same manner, providing natural stopping criteria and quality measures for realized devices. C

Introduction: The suitability of whole-genome sequencing (WGS) as the sole method to detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) was investigated with the aim of replacing current diagnostic methods. Methods: For this purpose, we assessed the analytical performance of 150 bp paired-end WGS (90x leukemia/30x germline). A set of 88 retrospective B-cell

A continuum damage framework is proposed for modelling the delamination process occurring in paperboard during mechanical loading. The main application of interest is line creasing and subsequent line folding used in package forming. To adequately capture creasing and folding, a continuum damage framework that uses a single isotropic damage variable that evolves with the plastic strains associated

Svensk tryck- och yttrandefrihet har en lång och stolt tradition. Men den har inte alltid stått pall mot censur och makthavares ingripanden.

We present the discovery of two exoplanets transiting TOI-836 (TIC 440887364) using data from TESS Sector 11 and Sector 38. TOI-836 is a bright (T = 8.5 mag), high proper motion (∼200 mas yr−1), low metallicity ([Fe/H]≈−0.28) K-dwarf with a mass of 0.68 ± 0.05 M and a radius of 0.67 ± 0.01 R. We obtain photometric follow-up observations with a variety of facilities, and we use these data sets to d

The interaction of K - with protons is characterised by the presence of several coupled channels, systems like K ¯ n and π Σ with a similar mass and the same quantum numbers as the K - p state. The strengths of these couplings to the K - p system are of crucial importance for the understanding of the nature of the Λ (1405) resonance and of the attractive K - p strong interaction. In this article,

BackgroundMuch longitudinal research has been carried out on non-suicidal self-injury (NSSI) during the last decades, but there still is a lack of studies of the individual developmental pathways of NSSI from adolescence into young adulthood. The aim of the present study was to investigate individual developmental pathways of repetitive non-suicidal self-injury (repNSSI) from adolescence into youn

During the twentieth century, a number of actors and institutions acrossthe global north set out to develop hierarchical social taxonomies of their national populations. Mainly used for the making of statistics, these divisions soon came to be influential in policy and public debates. Using mainly Swedish examples, this article offers new ways of understanding social taxonomies, thereby adding ins

Despite their detrimental circumstances, the number of refugee-owned businesses is on the rise—a situation referred to as “the paradox of refugee entrepreneurship.” However, a key question is how refugees, having undergone extreme life disruption due to war, conflict, and forced displacement, fare as entrepreneurs in their host country. Extant studies do not address this question, as they primaril

An argumentative text on the contribution of C02-emissions caused by academic flying.

Following the quantitative turn in linguistics, the field appears to be in amethodological “wild west” state where much is possible and new frontiers arebeing explored, but there is relatively little guidance in terms of firm rules orconventions. In this article, we focus on the issue of variable selection in regression modeling. It is common to aim for a “minimal adequate model” and eliminate “no

We review reduction and contraction in modalizing expressions of the type V-to- Vinf from the perspective of production, perception and mental representation.A corpus study of spoken American English shows reduction/contraction asa continuous process which is subject to phonological and communicative constraints. Generally, reduction (articulatory ease) is restricted by a tendencyto retain cues to

The guiding question of this paper is how (horizontal) connections are established when new items enter the network of constructions. It presents a quantitative, corpus-based study of the development of to-contraction (e.g. want to > wanna) in American English since the 19th century. From a plethora of earlier forms, gonna, wanna and gotta emerge, first as representations of phonetic reduction, bu