Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus- receptor (CAR) on the surface of target cell for efficient transduction, which limits it's utility for certain cell types. Herein we present a new vector, Ad5PTDf35, which is an Ad5 vector having seroty

Purpose The XPC gene is involved in DNA damage recognition in the nucleotide excision repair pathway (NER) We investigated the additive effects of single nucleotide polymorphisms (SNPs) in bladder-cancer patients and population controls for three XPC polymorphisms A499V (C>T) K939Q (A>C) and poly AT (PAT -/+) Experimental Design 311 bladder-cancer patients from a population-based cohort and 337 po

Aims. We study how diffuse interstellar bands (DIBs) measured toward distance-distributed target stars can be used to locate dense interstellar (IS) clouds in the Galaxy and probe a line-of-sight (LOS) kinematical structure, a potentially useful tool when gaseous absorption lines are saturated or not available in the spectral range. Cool target stars are numerous enough for this purpose. Methods.

The social surroundings in which an individual grows up and spends his or her everyday life have an effect on his or her life chances. Much of the research into this phenomenon focuses on so-called neighborhood effects and has put particular emphasis on the negative effects of growing up in a poor neighborhood. Originating from the sociological study of inner-city problems in the United States, th

Polysulfones functionalized with highly phosphonated poly(pentafluorostyrene) side chains of different length were synthesized applying controlled polymerization and modification methods. The graft copolymers' thermal properties were evaluated by differential scanning calorimetry and thermal gravimetrical analyses. The proton conductivity of membrane prepared from the graft copolymer with the shor

Cyperus fuscus was thought to be extinct in Sweden until it was rediscovered at Lake Vombsjön, Skåne, after 63 years in 2013. The species also occurred at the lake 2014—2021, but in very variable numbers. The variation depended largely on the water level during late summer. Favourable conditions in form of low levels in late summer have also occurred prior to 2013, though less frequently than in rCyperus fuscus was rediscovered at Lake Vombsjön in Skåne, southernmost Sweden, in 2013. The species occurred there between 1945 and 1950, which was the latest Swedish record except for a casual occurrence in a plant nursery. The comeback was spectacular with 2770 individuals counted along 4.7 km of the shore. In 2013, the water level was exceptionally low for technical reasons, with up to 100 m o

• Premise of the study: Small, autogamous flowers have evolved repeatedly in the plant kingdom. While much attention has focused on the mechanisms that promote the shift to autogamy, there is still a paucity of information on the factors that underlie the reduction of flower size so prevalent in selfing lineages. In this study of Crepis tectorum, I examine the role of inbreeding, acting alone or t

Abstract in UndeterminedThis article analyses the role of government effectiveness in the determination of informal employment. A theoretical model is developed, in which local governance and worker skill level are assumed to influence the decision of the worker whether to seek employment in the formal or informal sectors. The model is assessed empirically using data from Brazil, where almost half

OBJECTIVE: Employment rates are significantly lower among individuals with arthritis compared to a general population. There is, however, limited research about how men with arthritis perceive their ability to maintain working. The aim of this study was thus to explore their perception of this. PARTICIPANTS: Nine employed men with arthritis were purposively sampled. METHODS: Interviews were perfor

A distortional hardening elasto-plastic model at finite strains suitable for modeling of orthotropic materials is presented. As a prototype material, paperboard is considered. An in-plane model is established. The model developed is motivated from non-proportional loading tests on paperboard where the paperboard is pre-strained in one direction and then loaded in the perpendicular direction. A sof

The hyperfine structure of a large number of transitions in Al II cannot be described using A and B hyperfine constants and the hyperfine structure is therefore said to be anomalous. In this paper, we have studied the hyperfine structure of a few transitions in Al II, 3s5s(3)S-3s5p(3)P, 3s4d(3)D-3s5p(3)P and 3s5p(3)P-3s5d(3)D, by combining theory and experiment. It is shown that the anomalous hype

This paper proposes two novel iterative data-adaptive spectral estimation techniques for blood velocity estimation using medical ultrasound scanners. The techniques make no assumption on the sampling pattern of the emissions or the depth samples, allowing for duplex mode transmissions where B-mode images are interleaved with the Doppler emissions. Furthermore, the techniques are shown, using both

We investigate the interaction between propagating surface plasmons in silver nanowires and excitons generated in quantum dots. We show propagating surface plasmons can excite excitons, which results in quantum dot emission. In this process, the energy is directly transferred from the propagating surface plasmons to the excitons without converting to photons. Furthermore, we demonstrate the revers

Popular Abstract in Swedish Fibromodulin och dystrofin i ateroskleros; en populärvetenskaplig sammanfattning VAD ÄR ATEROSKLEROS? Ateroskleros – det man tidigare kallade för åderförkalkning – är grundorsaken till hjärtinfarkt, stroke och kärlkramp. Ett aterosklerosplack är en förträngning i ett blodkärl, ofta vid en förgrening där blodflödet är turbulent. Placket börjar ofta växa redan i unga år Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. This thesis discusses the importance of the connection between th

In this study, numerical simulations are conducted to investigate the effects of bowed outlet guide vanes (OGVs) on endwall heat transfer and aerodynamic performance. Both on- and off-design conditions are studied. For bowed vanes, the bowed angle varies from 10 degrees to 40 degrees and the normalized bowed height ranges from 0.1 to 0.3. Results are included for Nusselt number distributions on th

Fresh water availability and demand are unevenly distributed both temporally and geographically. Furthermore, the availability of fresh water has remained more or less constant, while the demand for clean water is steadily increasing. With demand surpassing supply, an integrated water resource management approach is required to ensure even distribution of potable water to all levels of society whi