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In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well a

Efficient time integration is a key issue in computational multibody dynamics. Implicit time integration methods for stiff systems and constrained systems require the solution of a system of nonlinear equations in each time step. The nonlinear equations are solved iteratively by Newton type methods that are tailored to the structure of the equations of motion in multibody dynamics. In the present

Popular Abstract in Swedish Många grundläggande processer i naturen involverar transport av energi från ett ställe till ett annat. Ett exempel på detta är fotosyntesen där solljus fångas upp av molekylkomplex, för att sedan transporteras till ett reaktionscenter. I reaktionscentret byggs den laddning upp som sedan används för att framställa växtmassa. För att minimera energiförlusten i den här typAn efficient transfer of energy in molecular systems has proven to be of fundamental importance both in nature and industrial applications. The ability of molecules to work together forming collective excitations, so-called excitons, plays a key role in for example the extraordinary fast energy transfer involved in the first steps of photosynthesis. The characterization of excitonic states in conj

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Popular Abstract in Swedish Människans blod cirkulerar runt i kroppen genom dess många blodkärl. Blodkärlen är till största del uppbyggda av två slags celler; endotelceller och glatta muskelceller. Endotelcellerna är placerade innanför de glatta muskelcellerna i blodkärlet och deras uppgift är att forma en barriär mot blodet. De glatta muskelcellernas funktion är att reglera blodflödet genom blodkContraction of blood vessels for the regulation of blood flow and pressure is dependent on vascular smooth muscle cells (VSMC) located in the medial layer of the vascular wall. Adult, differentiated VSMC have a well developed contractile system and a low rate of proliferation. Under the influence of hormones, growth factors, inflammatory mediators and tissue factors, cells may modulate to a ”synth

Background. When delivering an embedded product, such as a mobile phone, third party products, like games, are often bundled with it in the form of Java MIDlets. To verify the compatibility be- tween the runtime platform and the MIDlet is a labour-intensive task, if input data should be manually generated for thousands of MIDlets. Aim. In order to make the verification more efficient, we investiga

The interest in open source is high, which also goes for enterprise resource planning (ERPs) systems. In this article, we focus on the combination of open source and ERPs, and specifically on what role open source ERPs plays in the diffusion of ERPs among small and medium sized enterprises (SMEs). To be able to explain the interest in open source ERPs, we look into challenges, about which a propri

Abstract in UndeterminedA new phantom has been designed that can provide simultaneously different target to background activity ratios with a linearly changing diameter of lesions. The purpose of the study was to describe and perform initial measurements with the phantom aimed to characterize different nuclear medicine tomographic systems and reconstruction algorithms in their performance and beha

Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common types of progressive neurodegenerative disorder in our catchment area. The distribution of cortical degeneration in FTD is mainly the reverse of that in AD, while there are both differences and similarities in the clinical characteristics. Somatostatin and neuropeptide Y (NPY) are neuropeptides with a widespread distrib

The prospect of time controlled information processing with individual electrons in nanoscale systems provides strong motivation for investigations of coupled charge and energy transport properties of single electron sources. Building on our recent work [F. Battista et al., Phys. Rev. Lett. 110, 126602 (2013)] we investigate theoretically the statistical properties of temperature and potential flu