Duodenal levodopa infusion represents an effective strategy to manage motor and non-motor complications in patients with advanced Parkinson's disease (PD). However, most published clinical series regard small numbers of patients and do not exceed 1 year follow-up. In this multi-national observational cohort study conducted in seven specialised PD clinics and university hospitals we assessed long-t

Society depends on services provided by critical infrastructures, and hence it is important that they are reliable and robust. Two main approaches for gaining knowledge required for designing and improving critical infrastructures are reliability analysis and vulnerability analysis. The former analyses the ability of the system to perform its intended function; the latter analyses its inability to

von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. The variable phenotypes of VWD have given rise to a classification scheme that divides the disease into three types according to how it is manifest

Internet-delivered psychological treatment of major depression has been investigated in several trials, but the role of personalized treatment is less investigated. Studies suggest that guidance is important and that automated computerized programmes without therapist support are less effective. Individualized e-mail therapy for depression has not been studied in a controlled trial. Eighty-eight i

Background: Previous rhinomanometry studies have shown significant long-term variability of the nasal airway resistance and questioned the clinical validity of rhinomanonnetry. Research question: Could treatment with a topical glucocorticoid, budesonide, influence the long-term variability of active anterior rhinomanometry? Methods: Eight healthy volunteers participated in an unblinded controlled

In this paper, we present a random puncturing analysis of low-density parity-check (LDPC) code ensembles. We derive a simple analytic expression for the iterative belief propagation (BP) decoding threshold of a randomly punctured LDPC code ensemble on the binary erasure channel (BEC) and show that, with respect to the BP threshold, the strength and suitability of an LDPC code ensemble for random p

We have previously shown that leukotriene D(4) (LTD(4)), a known pro-inflammatory mediator, induces increased survival and proliferation of intestinal epithelial cells. In this study we examined whether LTD(4) functions via activation of the transcription factors NFkappaB and AP-1, which are potent inducers of mitogenesis. We found that the NFkappaB inhibitory protein IkappaBalpha was not degraded

This paper explores a formally grounded ap- proach to solve the problem of dynamic binding in service- oriented software architecture. Dynamic binding is a widely adopted mean to automatically bind exposed software interfaces to actual implementations. The execution of an operation on one or another implementation, though providing the same result, could turn out in different quality of service, e

Control allocation problems, in which optimal actuator values are assigned based on desired control actions and actuator constraints, are typically formulated as constrained optimization problems. Initially, only approximate solutions to the problems were deemed tractable for real-time applications. Recently however, active set algorithms have been identified as a means for solving control allocat

Electroconvulsive therapy (ECT) is an efficient and relatively fast acting treatment for depression. However, one severe side effect of the treatment is retrograde amnesia, which in certain cases can be long-term. The mechanisms behind the antidepressant effect and the amnesia are not well understood. We hypothesized that ECT causes transient downregulation of key molecules needed to stabilize syn

Syftet med artikeln är att utforska och förstå beskrivningar av och information om HPV-prevention utifrån olika positioner för att fånga samhälleliga och kulturella innebörder av HPV-vaccin. Två skolsköterskor intervjuades om sitt arbete med HPV-vaccinering, mediematerial om HPV-vaccin hämtades från Dagens Nyheter, Svenska Dagbladet och Sydsvenskans online-arkiv och informationsmaterial hämtades fThe aim of this article is to explore and understand information about HPV-prevention from several positions to grasp its social and cultural meanings. The material consists of interviews with two school nurses, material on HPV-vaccine from Swedish newspapers (Dagens Nyheter, Svenska Dagbladet, Sydsvenskan), and information from public authorities and pharmaceutical companies. In the analysis of t

Lipase has been encapsulated in ordered mesoporous materials in a one-step process. The procedure is simple and leads to well structured materials with enzyme loadings higher than those obtained through the post-synthesis approach. In the final bottle-around-the-ship material the enzyme would be entrapped in silica cages whose entrances are smaller than the enzyme itself. Therefore, reagents and p

Context. A number of large spectroscopic surveys of stars in the Milky Way are under way or are being planned. In this context it is important to discuss the extent to which elemental abundances can be used as discriminators between different (known and unknown) stellar populations in the Milky Way. Aims. We aim to establish the requirements in terms of precision in elemental abundances, as derive

Neuronal function depends on the properties of the synaptic inputs the neuron receive and on its intrinsic responsive properties. However, the conditions for synaptic integration and activation of intrinsic responses may to a large extent depend on the level of background synaptic input. In this respect, the deep cerebellar nuclear (DCN) neurons are of particular interest: they feature a massive b

Differential regulation as well as target gene specificity of the two hypoxia-inducible factor (HIF)-alpha subunits HIF-1alpha and HIF-2alpha in various tumors and cell lines have been suggested. In breast cancer, the prognostic significance of HIF-1alpha is not clear-cut and that of HIF-2alpha is largely unknown. Using IHC analyses of HIF-1alpha, HIF-2alpha, and vascular endothelial growth factor

Recension av Anna Whitelock, Elisabet I. Historien om drottningen och hennes förtrogna

Increasing evidence on associations between mental health and chronic diseases like cardio-vascular disease and diabetes together with the fact that little is known about the prevalence of anxiety/depression and associated risk factors among Iraqi immigrants to Sweden, warrants a study in this group. The aim was to study the prevalence of anxiety and depression in immigrants from Iraq compared to

The inclusive production cross sections at forward rapidity of , , (1S) and (2S) are measured in collisions at with the ALICE detector at the LHC. The analysis is based on a data sample corresponding to an integrated luminosity of 1.35 pb. Quarkonia are reconstructed in the dimuon-decay channel and the signal yields are evaluated by fitting the invariant mass distributions. The differential produc