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Developmental cues license megakaryocyte priming in murine hematopoietic stem cells

The fetal to adult switch in hematopoietic stem cell (HSC) behavior is characterized by alterations in lineage output and entry into deep quiescence. Here we identify the emergence of megakaryocyte (Mk) biased HSCs as an event coinciding with this developmental switch. Single-cell chromatin accessibility analysis reveals a ubiquitous acquisition of Mk lineage priming signatures in HSCs during the

Enhancing Rainfall-Runoff Simulation via Meteorological Variables and a Deep-Conceptual Learning-Based Framework

Accurate streamflow simulation is crucial for many applications, such as optimal reservoir operation and irrigation. Conceptual techniques employ physical ideas and are suitable for representing the physics of the hydrologic model, but they might fail in competition with their more advanced counterparts. In contrast, deep learning (DL) approaches provide a great computational capability for stream

Towards Social Negotiation : The Case of Handshake Debates in Sweden and Denmark

The refusal to shake hands with a female reporter by a Muslim politician from the Miljöpartiet resulted in a controversy in Sweden. Together with a number of court cases, it revealed a disparity between the established judicial line and the views of the general public. The Swedish controversy received a response from Denmark, where the ruling coalition introduced new citizenship legislation with a

Higher blood pressure in adolescent boys after very preterm birth and fetal growth restriction

BackgroundAlthough preterm birth predisposes for cardiovascular disease, recent studies in children indicate normal blood pressure and arterial stiffness. This prospective cohort study therefore assessed blood pressure and arterial stiffness in adolescents born very preterm due to verified fetal growth restriction (FGR).MethodsAdolescents (14 (13–17) years; 52% girls) born very preterm with FGR (p