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Perennial plants come with several benefits: less erosion, reduced intensity of farming operations, and increased carbon inputs into the soil. In a long term field experiment in Alnarp, Sweden, the perennial wheatgrass Kernza® is compared with an annual crop rotation (including wheat, sugar beet, barley and rapeseed), comparing the CO2 flux between the soil and the air together with other aspects https://www.youtube.com/watch?v=E94FUoaPqYk
Klimatförändringar förväntas öka frekvensen och intensiteten av klimatrelaterade risker, vilket i sin tur kan leda till så kallade Natech-olyckor, definierade som industriella olyckor där klimatrisker orsakar sekundära teknologiska händelser. Svenska industriverksamheter som hanterar farliga ämnen omfattas av Sevesolagstiftningen, där krav finns på att beakta sådana risker. Samtidigt är Natech-risClimate change is expected to increase the frequency and intensity of natural hazards, which in turn may lead to Natech accidents, defined as industrial accidents in which natural hazards trigger secondary technological events. Swedish industrial establishments that handle hazardous substances are subject to the Seveso legislation, which requires such risks to be taken into account. At the same ti
AimsDyspnoea accounts for nearly 5% of emergency department (ED) visits. Our aim was to describe the in-hospital and long-term outcomes of patients admitted to the ED for dyspnoea, based on their underlying aetiology, and to determine if prognosis varies according to the hospitalization setting.MethodsWe analyzed 18 903 consecutive patients (48% male, average age 73 years) hospitalized after an ED
OBJECTIVES: The National Board of Health and Welfare in Sweden published the national guidelines for Parkinson's Disease 2016. The aim of this study was to summarize this evidence review and development of the guidelines, focusing on the economic evaluation of device-aided therapies (deep brain stimulation, pump-based infusion of levodopa-carbidopa intestinal gel or apomorphine) for Parkinson's di
Atmospheric particulate matter (PM) contains different components that can elicit varying adverse health effects in humans and animals. Studies on PM toxicity and its underlying mechanisms in the middle ear are limited, and they generally use a PM standard. However, as PM composition varies temporally and geographically, it is crucial to identify the toxic PM constituents according to season and r
Cas9 nucleases are widely used for genome editing and engineering. Cas9 enzymes encoded by CRISPR-Cas defence systems of various prokaryotic organisms possess different properties such as target site preferences, size, and DNA cleavage efficiency. Here, we biochemically characterized CoCas9 from Capnocytophaga ochracea, a bacterium that inhabits the oral cavity of humans and contributes to plaque
Type II CRISPR-Cas9 RNA-guided nucleases are widely used for genome engineering. Type II-A SpCas9 protein from Streptococcus pyogenes is the most investigated and highly used enzyme of its class. Nevertheless, it has some drawbacks, including a relatively big size, imperfect specificity and restriction to DNA targets flanked by an NGG PAM sequence. Cas9 orthologs from other bacterial species may p
Protozoan parasites of the genus Leishmania cause leishmaniasis, a disease with variable clinical manifestations that affects millions of people worldwide. Infection with L. donovani can result in fatal visceral disease. In Panama, Colombia, and Costa Rica, L. panamensis is responsible for most of the reported cases of cutaneous and mucocutaneous leishmaniasis. Studying a large number of drug cand
The electrode's composition and structure, affecting ion-conduction and water uptake and transport, is crucial for polymer electrolyte fuel cells. This study investigates the role of particles versus dispersed ionomer based on poly(arylene piperidinium) (PAP) for AEMFC. Mixed ionomer electrodes, consisting of linear PAP ionomers and crosslinked particles, are synthesized and evaluated in AEMF
Heart failure (HF) is a complex clinical syndrome characterized by exercise intolerance. However, most diagnostic assessments are performed at rest, when many patients are asymptomatic. To better understand the underlying pathophysiology, examination during exercise is needed. Hydraulic force, a newly identified mechanism of diastolic filling, is proportional to the difference in short-axis areas
This paper explores the challenges and barriers of forced migrants at the nexus of housing and social integration, presenting the outcomes of an international and interdisciplinary collaboration funded by the JPI Urban Europe programme. Research includes the case study cities Leipzig, Lund, Riga, and Vienna, utilizing primary and secondary data in a transdisciplinary process involving theoretical
Det här kapitlet tar avstamp i en av dessa händelser ’från fältet’, i detta fall en teater, som hänger sig kvar många år efteråt men som inte använts eftersom den innehåller för många trådar: lite om metod, lite om etik, mycket om kroppar och om närvaro och om kön om man vill. Händelsen börjar i ett misstag som jag utnyttjar men sen får betala för och som väckte känslor både hos mig och hos den ja
Transformation in the contemporary architectural discourse does not only encompass the animation of form and program, which at the turn of the last century was progressed by deconstructivism and the digital turn. Applicable within aspects of ecology, economy, and culture, transformation has today evolved into a pervasive concept both advanced and abused within the complexity of forces that drive t
Saturated fatty acids impose lipotoxic stress on pancreatic β cells, leading to β cell failure and diabetes. In this study, we investigate the critical role of organellar Ca2+ disturbance on defective autophagy and β cell lipotoxicity. Palmitate, a saturated fatty acid, induced perilysosomal Ca2+ elevation, sustained mTOR complex 1 (mTORC1) activation on the lysosomal membrane, suppression of the
The use of CRISPR-Cas bacterial adaptive immunity system components for targeted DNA changes has opened broad prospects for programmable genome editing of higher organisms. The most widely used gene editors are based on the Cas9 effectors of the type II CRISPR-Cas systems. In complex with guide RNAs, Cas9 proteins are able to directionally introduce double-stranded breaks into DNA regions that are
Pathological processes often change the mechanical properties of cells. Increased rigidity could be a marker of cellular malfunction. Erythrocytes are a type of cell that deforms to squeeze through tiny capillaries; changes in their rigidity can dramatically affect their functionality. Furthermore, differences in the homeostatic elasticity of the cell can be used as a tool for diagnosis and even f
We examine key characteristics of the work tasks of judges and prosecutors from a power and status perspective, discerning how emotions tie into this perspective. Analysis of court observations, interviews and shadowing of judges and prosecutors at four Swedish district courts and prosecution offices shows that power and status operate differently for the respective professions, resulting in distiWe examine key characteristics of the work tasks of judges and prosecutors from a power and status perspective, discerning how emotions tie into this perspective. Analysis of court observations, interviews and shadowing of judges and prosecutors at four Swedish district courts and prosecution offices shows that power and status operate differently for the respective professions, resulting in disti
Objectives To investigate changes in analgesic use before and after supervised exercise therapy and patient education in patients with knee or hip osteoarthritis (OA).Methods We recruited 16 499 of 25 933 eligible patients (64%; mean age 64.9; SD 9.6; 73% women) from the Good Life with osteoArthritis in Denmark (GLA:D) registry. Change in proportions of analgesic users (categorised according to an
