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Assessment and Treatment of Impaired Insulin-Secretion and Action in Type 2 Diabetes Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic cont

https://www.ludc.lu.se/education-training/theses/theses-2008/mozhgan-dorkhan - 2026-07-11

Adipose Tissue Gene Expression & Candidate Genes for Obesity Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene

https://www.ludc.lu.se/education-training/theses/theses-2008/lovisa-e-johansson - 2026-07-11

Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scans and Candidate Genes to Genome Wide Association Studies Type 2 diabetes (T2D) and metabolic syndrome (MetS) are major health problems associated with cardiovascular disease. Both diseases are influenced by a combination of genetic and environmental factors. The aim of this thesis was to identify genetic risk factors

https://www.ludc.lu.se/education-training/theses/theses-2008/marketa-sjogren - 2026-07-11

Beta-Cell Dysfunction in Huntington´s Disease Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocri

https://www.ludc.lu.se/education-training/theses/theses-2009/karl-bacos - 2026-07-11

The Impact of Ethnicity on type 2 Diabetes Type 2 diabetes mellitus is among the fastest growing diseases in the world. The reported prevalence of T2D appears to differ among various ethnic groups. Although ethnic-related differences in lifestyle factors may account for some of the predisposition to diabetes in various ethnic groups, genetic factors may play a more determinant role.High prevalence

https://www.ludc.lu.se/education-training/theses/theses-2009/forouzan-glans - 2026-07-11

Mitochondrial and Chromosomal Genomics in Type 2 Diabetes Understanding the mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. Since majority of the mitochondrial genes are encoded by the nuclear gen

https://www.ludc.lu.se/education-training/theses/theses-2009/avinash-abhyankar - 2026-07-11

Beta Cell Function: from Human Genetics to Animal Models Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence

https://www.ludc.lu.se/education-training/theses/theses-2009/martins-kalis - 2026-07-11

Integrating bioinfomatics and physiology to describe genetic affects in complez polygenic diseases Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. This thesis has focused on dissecting the gene

https://www.ludc.lu.se/education-training/theses/theses-2009/hemang-parikh - 2026-07-11

Exploring the Grey Zone between Type 1 and Type 2 Diabetes T1D is most common in children and young adults and is characterized by autoimmune destruction of insulin producing pancreatic beta cells, presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA),

https://www.ludc.lu.se/education-training/theses/theses-2009/ekaterine-bakhtadze - 2026-07-11

Genetic and Metabolic Markers for the Development of Diabetes after Gestational Diabetes Mellitus The aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify poss

https://www.ludc.lu.se/education-training/theses/theses-2010/magnus-ekelund - 2026-07-11

Regulation of Glucagon Secretion from pancreatic alpha cells Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like pancreatic β-cells, which produce insul

https://www.ludc.lu.se/education-training/theses/theses-2010/yang-zhang-de-marinis - 2026-07-11

Molecular Etiology of Graves´ Disease and Associated Ophthalmopathy Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we de

https://www.ludc.lu.se/education-training/theses/theses-2010/tereza-planck - 2026-07-11

The Role of Genetic Variation and DNA Methylation in Human Glucose Metabolism and Type 2 Diabetes The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thes

https://www.ludc.lu.se/education-training/theses/theses-2010/tina-ronn - 2026-07-11

New aspects of voltage-gated calcium channel regulation in pancreatic beta-cells. Relevance for insulin release and type 2 diabetes Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose low

https://www.ludc.lu.se/education-training/theses/theses-2011/thomas-reinbothe - 2026-07-11

Triggers of autoimmunity. Studies on gestational events The primary aim of this thesis was to test whether gestational exposure to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure to viruses or other environmental factors is a risk factor for type 1 diabetes in the offspring. As children with type 1 diabetes have a higher risk of deve

https://www.ludc.lu.se/education-training/theses/theses-2011/sabina-lindehammer - 2026-07-11

Adaptive immune responses in atherosclerosis: Or how to prolong the use of your yellow socks Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is

https://www.ludc.lu.se/education-training/theses/theses-2011/daniel-kolbus - 2026-07-11

Genetic Variants and the Risk of Type 2 Diabetes Type 2 diabetes is rapidly increasing worldwide thereby posing a severe burden on individual and public health. Although this increase can be ascribed to both genetic and environmental factors, until 2007, the genetic factors have been largely restricted to a few candidate genes based upon our limited knowledge of the pathogenesis of the disease. In

https://www.ludc.lu.se/education-training/theses/theses-2011/anna-jonsson - 2026-07-11

Search for molecular and metabolic mechanisms contributing to impaired bet-cell function Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for

https://www.ludc.lu.se/education-training/theses/theseis-2012/siri-malmgren - 2026-07-11

Exocytosis in Type 2 Diabetes - Functional and Genetic Studies of Hormone Secretion Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts

https://www.ludc.lu.se/education-training/theses/theses-2012/sofia-andersson - 2026-07-11

Genetic and Epigenetic Influence on Oxidative Phosphorylation, Islet Function and Type 2 Diabetes in Humans The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistanc

https://www.ludc.lu.se/education-training/theses/theses-2012/anders-h-olsson - 2026-07-11