Several studies have shown decreased cerebral blood flow (CBF) in Alzheimer's disease (AD). However, the role of hypoperfusion in the disease pathogenesis remains unclear. Combining arterial spin labeling MRI, PET, and CSF biomarkers, we investigated the associations between gray matter (GM)-CBF and the key mechanisms in AD including amyloid-β (Aβ) and tau pathology, synaptic and axonal degenerati

BACKGROUND AND PURPOSE: Myeloablative Total Body Irradiation (TBI) is an important modality in conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), especially in children with high-risk acute lymphoblastic leukemia (ALL). TBI practices are heterogeneous and institution-specific. Since TBI is associated with multiple late adverse effects, recommendations may help to standardi

This article analyzes how Swedish digital media influencers make sense of their careers in print media interviews and autobiographical books. I explore how influencers use meta-phors involving motion, speed and acceleration to describe, explain and legitimate the various circumstances and phases of their career development, and how these metaphors may be viewed in the wider context of social accel

Premise: Flower phenotypes evolve to attract pollinators and to ensure efficient pollen transfer to and from the bodies of pollinators or, in self-compatible bisexual flowers, between anthers and stigmas. If functionally interacting traits are genetically correlated, response to selection may be subject to genetic constraints. Genetic constraints can be assessed by quantifying standing genetic var

Om fotbollshistoria

What drives the adoption of pottery amongst prehistoric foragers in high-latitude environments? Following the long-running interests of archaeology in explaining the origin and dispersal of new technologies, recent years have seen growing efforts to understand what drove the emergence and expansion of early hunter-gatherer pottery use across northern Eurasia. However, many regional dimensions to t

Turbulent emulsification is of considerable industrial interest. Nevertheless, numerical experiments (direct numerical simulations, DNS, with highly resolved interface tracking) have been mainly used to study drop breakup in idealized flows. This study, therefore, compares drop breakup in two different settings (homogenous and isotropic flow, and a simplified high-pressure homogenizer) with the in

Value is a key concept in public service logic. However, exactly what the concept of value brings to public services, where the value of a service cannot be linked to a cost or a payment, has not received much attention. In this article, examples are shown of how value is expressed empirically by a corpus based on interviews with various stakeholders in a municipal service context. The study prese

Real-time prediction of train arrivals is important for proactive traffic control and information provision in passenger rails. Despite many studies in predicting arrival times or delays at stations, they are essentially the next-step time series prediction problem which may limit their applications in practice. For example, passengers on the trains or waiting on platforms may have different desti

• The Arctic is continuing to warm faster than any other region on Earth, but key uncertainties remain in our knowledge of the Arctic carbon cycle. • We review the most current knowledge pertaining to estimates of arctic greenhouse gas components and discuss uncertainties associated with these measurements and models. • While the Arctic Ocean is consistently estimated as a carbon sink, we have yet

IMPORTANCE: Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing is needed.OBJECTIVE: To determine the effect of different doses of extended-release morphine on worst breathlessness in people with COPD after 1 week of treatment.DESIGN, SETTING

Purpose: Exposure to cold air may harm the airways. It is unclear to what extent heavy exercise adds to the cold-induced effects on peripheral airways, airway epithelium, and systemic immunity among healthy individuals. We investigated acute effects of heavy exercise in sub-zero temperatures on the healthy airways. Methods: Twenty-nine healthy individuals underwent whole body exposures to cold air

Pediatric neuroradiology is a subspecialty within radiology, with possible pathways to train within the discipline from neuroradiology or pediatric radiology. Formalized pediatric neuroradiology training programs are not available in most European countries. We aimed to construct a European consensus document providing recommendations for the safe practice of pediatric neuroradiology. We particula