Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of Europe

To facilitate early prophylaxis, step-up regimens starting prophylaxis with infusions 1xweek(-1) were introduced. Choice of initial regimen may affect outcome. This study aims to classify initial prophylactic regimens and compare them on short-term outcome. From the European Paediatric Network for Haemophilia Management' (PedNet) registry, patients with severe haemophilia A without inhibitors, bor

Input data for communication network design/optimization problems involving multi-hour or uncertain traffic can consist of a large set of traffic matrices. These matrices are explicitly considered in problem formulations for link dimensioning. However, many of these matrices are usually dominated by others so only a relatively small subset of matrices would be sufficient to obtain proper link capa

A cut-off of 9.8% maximum speckle-tracking radial strain in the segment with the latest mechanical delay has been proposed as predictive for selecting the best left ventricular lead placement for positive response on cardiac resynchronization therapy (CRT). However, pacing transmural scar should be avoided, and the purpose of this study was to evaluate the ability of echocardiographic radial strai

Since the discovery of short, regulatory microRNAs (miRNA) 20 years ago, the understanding of their impact on gene regulation has dramatically increased. Differentiation of cells requires comprehensive changes in regulatory networks at all levels of gene expression. Posttranscriptional regulation by miRNA leads to rapid modifications in the protein level of large gene networks, and it is therefore

The phenomenon of adopting open source software development practices in a corporate environment is known by many names, one being inner source. The objective of this study is to investigate how an organization consisting of small development teams can benet from adopting inner source and assess the level of applicability. The research has been conducted as a case study at a software development c

In this paper we propose a new algorithm for solving the Learning With Errors (LWE) problem based on the steps of the famous Blum-Kalai-Wasserman (BKW) algorithm. The new idea is to introduce an additional procedure of mapping subvectors into codewords of a lattice code, thereby increasing the amount of positions that can be cancelled in each BKW step. The procedure introduces an additional noise

A new extracellular flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenase from Glomerella cingulata (GcGDH) was electrochemically studied as a recognition element in glucose biosensors. The redox enzyme was recombinantly produced in Pichia pastoris and homogeneously purified, and its glucose-oxidizing properties on spectrographic graphite electrodes were investigated. Six different Os

Available safe egress time is an important criterion to determine occupant safety in performance-based fire protection design of buildings. There are many factors affecting the calculation of available safe egress time, such as heat release rate, smoke toxicity and the geometry of the building. Heat release rate is the most critical factor. Due to the variation of fuel layout, initial ignition loc

This research aims at contributing to the literature on global sourcing and particularly to the literature on global sourcing development over time. Using case study materials on the home furnishing retailer IKEA, this research constitutes a picture of the sourcing landscape of IKEA from the 1950s onward. The case of IKEA’s global sourcing development over time is discussed over three dimensions:

In-hospital patients may suffer unexpected death because of suboptimal monitoring. Early recognition of deviating physiological parameters may enable staff to prevent unexpected in-hospital death. The aim of this study was to evaluate short- and long-term effects of systematic interprofessional use of early warning scoring, structured observation charts, and clinical algorithms for bedside action.

Abstract Objectives. Pulmonary hypertension (PH) due to left heart disease may impair outcome after heart transplantation (HT). To evaluate to what extent previous, and present, haemodynamic criteria discriminate the impact of pre-operative-PH on survival, we characterized the PH in our HT-patients according to ESC's guidelines, ISHLT's summary statement and ISHLT's relative contraindications and

BK virus associated nephropathy occurs in approximately 5% of renal transplant recipients. Quantitation of BKV DNA in serum/plasma early in the course of disease has been suggested to be an important diagnostic tool for polymavirus-associated nephropathy (PVAN). The aim of this study was to develop a BKV real-time PCR (qPCR), which could be included in a diagnostic qPCR platform. Additionally, the

The compound semiconductor RuS2, known as mineral laurite, has been investigated as a potential (photo) electrochemically active anode material for the oxygen evolution in the process of (photo) electrolytic water splitting. The contribution describes for the first time the preparation of RuS2 thin films deposited on (100)- and (111)-oriented FeS2 (pyrite) substrates using reactive magnetron sputt

The genus Katatopygia gen. n. is proposed for the Boletina erythropyga/punctus-group that was first introduced by Garrett (1924, 1925) and currently comprises eight described species. Molecular studies have strongly indicated that this group forms a monophyletic sister-group to a clade consisting of all other Boletina, Coelosia and Gnoriste, and its monophyly is supported by morphological data as

Thermal-optical analysis is a conventional method for determining the carbonaceous aerosol fraction and for classifying it into organic carbon, OC, and elemental carbon, EC. Unfortunately, the different thermal evolution protocols in use can result in a wide elemental carbon-to-total carbon variation by up to a factor of five. In Europe, there is currently no standard procedure for determining the

We investigated possible hemispheric differences in the processing of four different lexical semantic categories: SPECIFIC (e.g. bird), GENERAL (e.g. animal), ABSTRACT (e.g. advice), and EMOTIONAL (e.g. love). These wordtypes were compared using a dichotic listening paradigm and a semantic category classification task. Response times (RTs) were measured when participants classified testwords as co

Two new Geissleria species from Siberian mountain lakes Baikal and Frolikha are described based on molecular and morphological data. The two new species are Geissleria baicalosimilis Kulikovskiy, Gusev, Andreeva & Annenkova sp. nov. and G. frolikhiensis Kulikovskiy, Gusev, Andreeva & Annenkova sp. nov. According to partial 18S rDNA and rbcL gene fragment analyses, Geissleria does not belon