Our research The brain´s basal ganglia elaborate information from multiple sources to shape and select our movements and thoughts. These functions are heavily dependent on signals that originate from dopamine cells in the midbrain. Dopamine cells degenerate in Parkinson´s disease (PD) giving rise to typical motor and non-motor deficits. With our research, we pursue pathophysiological mechanisms an

https://www.multipark.lu.se/basal-ganglia-pathophysiology - 2025-05-05

Andreas Heuer Our research We are interested in preclinical rodent models of neurodegenerative diseases with a focus on non-motor symptoms. We use these models to test treatments like cell replacement therapy and gene therapy. For that purpose, we use technologies that allow for the reversible manipulation of cell activity (opto- and chemogenetics), technologies that allow for the recording of neu

https://www.multipark.lu.se/behavioral-neuroscience-laboratory - 2025-05-05

Other strategic grants give you the opportunity to obtain co-funding when inviting scientific guests to give lectures or when organizing scientific conferences. The granted amount can be used to cover travel and accommodation costs in connection with the event. Please indicate if food/drinks are requested and indicate an amount. Costs for subsistence allowance (“traktamente”) are not eligible. Tri

https://www.multipark.lu.se/funding-opportunities/other-strategic-grants - 2025-05-05

Our research Our projects focus is to investigate the role of neuroinflammation in neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease and stroke. Microglia are the major immune cells in the brain. Therefore, the majority of our projects aim to explore the function of these cells and to determine how they contribute to health and disease. In addition, we investigate how

https://www.multipark.lu.se/experimental-neuroinflammation-laboratory - 2025-05-05

Our research Dementia is a major public health concern globally but treatments have so far been inadequate. Our focus is to understand the early molecular and cellular pathology that we see initiating in synapses in Alzheimer’s disease, the most common neurodegenerative disease. It remains imperative that academic researchers uncover early steps in the disease process, rather than only translating

https://www.multipark.lu.se/experimental-dementia-research - 2025-05-05

Our research The human brain is a highly complex structure, consisting of hundreds of different subtypes of neurons; each of which fulfill a specific function in the brain network. When some of these neurons are lost – such as in neurodegenerative diseases – our brains become malfunctioning. The goal of our research is to develop stem cell-based therapies to replace lost neurons as a treatment for

https://www.multipark.lu.se/human-neural-development - 2025-05-05

Our research We develop new microfluidic and acoustofluidic technology to create spatially and temporally controlled microenvironments for cell culturing and to manipulate biological matter in the microscale. This will provide new strategies for stem cell differentiation, novel means to study cell/tissue drug response, and new techniques for cell separation as well as submicron particle separation

https://www.multipark.lu.se/nanobiotechnology-and-lab-chip - 2025-05-05

Our research We conduct research and education with a focus on disability and rehabilitation. The target groups are individuals of all ages with neurologic disabilities as a result of stroke, traumatic brain injury, spinal cord injury, post-polio, multiple sclerosis, Parkinson’s disease, and neuromuscular disorders, and children, adolescents and adults with non-malignant pain. The research group i

https://www.multipark.lu.se/rehabilitation-medicine - 2025-05-05

Our research In the gene therapy group, our main interest is to develop systems for sufficient and sustained expression of transgenes in the CNS. We are using gene transfer to express trophic factors or neurotransmitter-producing enzymes in animal models of neurodegenerative disease. We are currently working with three different vector systems: adeno-associated viral, retroviral and lentiviral. Th

https://www.multipark.lu.se/cns-gene-therapy - 2025-05-05

Lund Brain Injury laboratory for Neurosurgical research Our research Traumatic brain injury (TBI) is a common cause of death and disability and current treatment options are limited. TBI is also a risk factor for neurodegeneration and dementias. Beta-amyloid (Aβ) and tau aggregations, hallmark findings of Alzheimer´s disease, are also observed in TBI. Therefore, we explore the link between TBI, ag

https://www.multipark.lu.se/translational-neurotrauma-group - 2025-05-05

Our research We make images of the tissue microstructure using the MRI scanner. This could enable better diagnosis by detecting subtle changes in the organization of tissue at an early stage of the disease. The approach is based on diffusion MRI (dMRI), where water molecules probe tissue microstructure. Conventional dMRI yields metrics such as mean diffusivity and fractional anisotropy, regarded a

https://www.multipark.lu.se/multidimensional-microstructure-imaging - 2025-05-05

Our research The overall goal of the present project is to improve care and treatment as well as the quality of life for people with Parkinson's disease (PD). This will be done through improved detection, understanding, and treatment of the non-motor symptomatology in PD. We continuous monitor the PD symptomatology to improve our understanding for earlier detection. Further, we develop advanced PD

https://www.multipark.lu.se/restorative-parkinson-unit - 2025-05-05

Our research Organic Bioelectronic Neuropharmacology, electroceuticals for the nervous system - Our ambition is to supplement biochemical signaling with electronic functionalities using both galvanic (ion) and faradic (electron) processes. Traditional medicines are based on biochemical principles without regard to electrical properties. We focus on organic electronics that are self-assembled direc

https://www.multipark.lu.se/chemical-biology-therapeutics - 2025-05-05

Our research My group works with translational stem cell biology. The focus of my research is to understand cell fate specification in the developing brain and in human neural progenitor cells, using cell-based models of neuronal differentiation. Our current focus is to learn how to direct and efficiently drive controlled differentiation of human stem cells into subtype-specific neurons. We also d

https://www.multipark.lu.se/developmental-and-regenerative-neurobiology - 2025-05-05

Our research Neurovascular changes are now increasingly recognized as a common denominator of many neurodegenerative disorders. In my group, we examine how microvascular alterations at the blood-brain barrier contribute to the pathogenesis of neurodegeneration. Our special focus is on pericytes as key players in inflammation and neurodegeneration and potential target cells for brain repair. Using

https://www.multipark.lu.se/translational-neurology - 2025-05-05

Our research The Translational Neuroendocrine Research Unit (TNU) focuses on Huntington’s disease (HD). Furthermore, we study the spectrum of amyotrophic lateral sclerosis (ALS) and the behavioral variant of frontal temporal dementia (bvFTD). These are fatal neurodegenerative disorders without effective disease-modifying therapies. Although research has previously focused on the well-known disturb

https://www.multipark.lu.se/translational-neuroendocrinology - 2025-05-05

Our research Our group studies genetic causes of Parkinson’s disease (PD) and other neurological/neurodegenerative movement disorders. Emphasis presently lies on patients and families with inherited disease forms, where mutations in a single gene cause the disease. Such genetic disease forms offer the possibility to discover and study novel disease mechanisms. Genetic testing is increasingly used

https://www.multipark.lu.se/clinical-neurogenetics - 2025-05-05

Our research Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. Our work focuses on the interactions between glia and neurons. We are constantly developing new and robust human stem cell-based models which we utilize to understand cell autono

https://www.multipark.lu.se/stem-cell-laboratory-cns-disease-modeling - 2025-05-05

Our research Our research is focused on identifying cellular and molecular mechanisms contributing to circuit remodeling in the postischemic brain. In particular, we are interested in how the activation of dopamine signaling cascades modulates processes of adaptive neuronal plasticity. Identifying specific dopamine-driven targets may provide candidates for a recovery-enhancing adjuvant pharmacolog

https://www.multipark.lu.se/laboratory-experimental-brain-research - 2025-05-05

Our research We focus on finding protective factors for neurodegenerative disorders, with emphasis on Parkinson’s disease (PD). Our strategy is to identify risk factors in genes, lifestyle and environment, to learn about the underlying causes for disease, and how to interfere with these. In this quest, we combine molecular biology with in vitro and in vivo models and studies in clinical materials.

https://www.multipark.lu.se/translational-neurogenetics - 2025-05-05