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Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum

The aim of this study was to evaluate the efficacy and toxicity of paclitaxel given at the same dose intensity and administered weekly (arm A) or every 3 weeks (arm B), and to assess the safety of intravenous steroids versus standard peroral premedication. Two hundred and eight patients with advanced ovarian cancer previously treated with no more than one platinum-containing regimen were randomize

Repressing NOx and N2O emissions in a fluidized bed biomass combustor

The emission of NOx and-N2O were studied experimentally in a fluidized bed biomass combustor. To investigate effectively the influence of different parameters on the NOx formation with a limited number of experiments, an orthogonal experimental design was adapted. Four biomass fuels, three NOx-repressing additives, four bed materials, and four alkali-capturing additives were tested in a temperatur

Dating of some Romanian fossil bones by combined nuclear methods

A set of fossil bones from Romania has been analysed by accelerator mass spectrometry and by neutron activation analysis in order to estimate their age. The temporal attributing of Malu Rosu archaeological settlement has been extensively analyzed. The radiocarbon age, determined by accelerator mass spectrometry, for this site is 5510+/-200 BP. This is in agreement with the age of 6000+/-2000 BP, o

Leisure activities in rheumatoid arthritis: Change after disease onset and associated factors

The objective of this investigation was to examine the relationship between leisure-time occupations, quality of life disease activity among patientswith rheumatoid arthritis. Fifty patients with rheumatoid arthritis-39 females and 11 males, age 30-45 years and belonging to functional class I-III according to Steinbrocker er al (1949)-were recuited from the register at a hospital clinic and from a

Filosofisociologi : Ett sociologiskt perspektiv på filosofiskt tänkande

Popular Abstract in Swedish Ämnet för föreliggande avhandling är filosofisociologi. Filosofisociologin är en underavdelning till kunskapssociologin. Som framgår av namnet intresserar sig denna disciplin för det sociologiska studiet av filosofin. I och med att detta område är tämligen outforskat är denna avhandling i hög grad explorativ till sin karaktär. Betraktad som en helhet syftar avhandlingenThe subject matter of the present doctoral thesis is the sociology of philosophy, a sub-discipline within the general field of sociology. As the term clearly indicates, the sociology of philosophy concerns the sociological study of philosophy. As this domain is still, to some extent, virgin territory, my thesis is mainly explorative in nature. Viewed as a whole, it aims at investigating what a soc

Urine excretion of protein HC in proteinuric glomerular diseases correlates to urine IgG but not to albuminuria

BACKGROUND: Proteinuric glomerular diseases often are associated with tubulointerstitial injury, which imposes on the progression of renal failure. Tubular damage is partly referable to toxic effects on the tubular epithelial cells induced by filtered plasma proteins. Patients with nonselective proteinuria, that is, increased urine excretion of high-molecular-weight plasma proteins such as IgG in

Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins.

Context: Adiponectin is a key insulin-sensitizing adipokine acting on muscle metabolism via two specific receptors [adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively)]. Objectives: The aim of the study was to investigate the genetic and nongenetic control of plasma adiponectin and muscle AdipoR1/R2 gene expression and the impact of these components on in vivo glucose and fat metabo

The role of the leukemia-associated ETO homologue repressors in hematopoiesis

Popular Abstract in Swedish Blodet fyller livsviktiga uppgifter i kroppen såsom syretransport och infektionsförsvar. De röda blodkropparna sköter syretransporten och de vita blodkropparna hanterar infektionsskyddet eller immunförsvaret. Blodplättar står för blodets levring vid blödning. Efterhand förbrukas blodcellerna och därför sker en kontinuerlig nybildning. Vid akut behov kan produktionen av The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was identified from the cloning of AML1-ETO. Subsequently, MTGR1 (Myeloid Translocation Gene-Related protein 1

Patterns of normal change in cervical length and width during pregnancy in nulliparous women: a prospective, longitudinal ultrasound study

OBJECTIVES: To determine what constitutes normal changes in the uterine cervix visible at transvaginal ultrasound examination from 24 gestational weeks until delivery in nulliparous women delivering at term. DESIGN: Cervical length and width were measured using transvaginal ultrasound, and the inner cervical os was assessed as being closed or open every 2 weeks from gestational week 24 until deliv

District Heating for Residential Areas with Single-Family Housing -with Special Emphasis on Domestic Hot Water Comfort

Popular Abstract in Swedish Konceptet fjärrvärme inbegriper central värmeproduktion från vilken värme distribueras ut till de enskilda förbrukarna via ett rörsystem. Ett grundläggande krav, med hänsyn till fjärrvärmens konkurrenskraft, är att vinsten som görs i den storskaliga värmeproduktionen, jämfört med lokal värmeproduktion, överstiger kostnaderna för värmedistributionen. DistributionskostnadThe concept of district heating (DH) involves centralised heat production where heat is distributed to consumers via a piping network. It is essential that benefits achieved from concentrated, large-scale production instead of local production in each building exceed the costs associated with heat distribution. Since the distribution cost per delivered kWh increases as the heat density of an area

Phase transition to frequency entrainment in a long chain of pulse-coupled oscillators

A long chain of pulse-coupled oscillators was studied. The oscillators interacted via a phase response curve similar to those obtained from pacemaker cells in the heart. The natural frequencies were random numbers from a distribution with finite bandwidth. Stable frequency-entrained states were shown always to exist above a critical coupling strength. Below the critical coupling, the probability t

Passive smoking and childhood asthma. Urinary cotinine levels in children with asthma and in referents

Passive exposure to tobacco smoke was assessed in children with asthma (age 3-15) and in referents. There was statistically significantly (P less than 0.0005) higher excretion of the nicotine metabolite, cotinine, in the urine of 49 children with asthma (geometric mean 10 ng/ml) compared with 77 referents (4.8 ng/ml). Maternal smoking was statistically significantly more prevalent among the asthma

Driving forces of phase transitions in surfactant and lipid systems

In aqueous surfactant and lipid systems, different liquid crystalline phases are formed at different temperatures and water contents. The "natural" phase sequence implies that phases with higher curvature are formed at higher water contents. On the other hand, there are exceptions to this rule, such as the monoolein/water system. In this system an anomalous transition from lamellar to reverse cubi