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Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. Objective To characterize the survival of BRCA carriers with EOC compared with noncarriers and to determine whether BRCA1 and BRC
By applying a novel approach to evaluate photofragmentation laser-induced fluorescence (PFLIF) imaging, experimental quantitative information on the temporal in-cylinder distribution of hydrogen peroxide (H2O2) in a homogeneous charge compression ignition (HCCI) engine was extracted. The results from PFLIF were then compared to those obtained from chemical kinetics simulations using computational
Within the heavy baryon chiral perturbation theory approach, we have studied the leading logarithm behavior of the nucleon mass up to four-loop order exactly and we present some results up to six-loop order as well as an all-order conjecture. The same methods allow to calculate the main logarithm multiplying the terms with fractional powers of the quark mass. We calculate thus the coefficients of
Objectives. Primary hyperparathyroidism (PHPT) is associated with cardiovascular disease. The aims of this study were to investigate lipid and glucose metabolism in mild PHPT, and to identify whether insulin sensitivity correlates with circulating levels of adiponectin, SHBG, and osteocalcin before and after parathyroidectomy (PTX). Materials and methods. Forty-five patients with PHPT were examine
Isotropic diffusion weighting is employed in diffusion NMR and MRI for rapid determination of the trace of the diffusion tensor and for showing the presence of microscopic diffusion anisotropy in a globally isotropic material. In the recently introduced q-MAS PGSE sequence, short gradient pulses define the beginning and the end of the diffusion time by quickly increasing and reducing the magnitude
Background: Survival of people with HIV-2 and HTLV-1 infection is better than that of HIV-1 infected people, but long-term follow-up data are rare. We compared mortality rates of HIV-1, HIV-2, and HTLV-1 infected subjects with those of retrovirus-uninfected people in a rural community in Guinea-Bissau. Methods: In 1990, 1997 and 2007, adult residents (aged >= 15 years) were interviewed, a blood sa
We compare LDPC block and LDPC convolutional codes with respect to their decoding performance under low decoding latencies. Protograph based regular LDPC codes are considered with rather small lifting factors. LDPC block and convolutional codes are decoded using belief propagation. For LDPC convolutional codes, a sliding window decoder with different window sizes is applied to continuously decode
Rapid and automatic processing of grammatical complexity is argued to take place during speech comprehension, engaging a left-lateralized fronto-temporal language network. Here we address how neural activity in these regions is modulated by the grammatical properties of spoken words. We used combined magneto- and electroencephalography to delineate the spatiotemporal patterns of activity that supp
Objective To identify predictors of response to methotrexate (MTX) in early rheumatoid arthritis (RA). Methods In the SWEFOT trial, patients with RA with symptom duration <1 year started MTX monotherapy (20 mg/weekly) and 405/487 continued until the 3-4-month visit. The primary outcome measure was the DAS28-based European League against Rheumatism (EULAR) response criteria. Multivariate logistic r
Inter-pigment interactions define the functioning of light-harvesting protein complexes. To describe the particularly complex molecular dynamics and interactions of peridinin and chlorophyll in the peridinin chlorophyll protein of Amphidinium carterae, we applied global and target analysis to a series of ultrafast transient absorption experiments. We have created and validated a model that consist
Physical inactivity has been identified as the fourth leading risk factor for global mortality and healthcare systems play a major role in increasing physical activity among the population. Physical activity on prescription (PAP) is a non-pharmacological method used in Swedish healthcare to prevent and treat disease. Primary health care is the first level of care, in a strong position to work for
Understanding the mechanisms of deformation and failure of soils is essential in geotechnical engineering. In particular, strain localisation is a key issue for the failure of soils. In laboratory mechanical testing, localised deformation can be investigated efficiently through full-field measurements of displacement and strain in soil specimens. The objective of this study is to investigate the d
ESA's Soil Moisture and Ocean Salinity (SMOS) mission has been designed to extend our knowledge of the Earth's water cycle. Soil Moisture and Ocean Salinity records brightness temperatures at the L-band, which over land are sensitive to soil and vegetation parameters. On the basis of these measurements, soil moisture and vegetation opacity data sets have been derived operationally since 2009 for a
This article proceeds from a critical reading of the role of religion for nation-building in India. In particular, the authors discuss how the Indian notion of secularism relies upon a number of religious legacies manifest in a Gandhian notion of what constitutes religious and political communities. Proceeding from this general picture, the authors examine how Hindu nationalists have used such leg
Sammanfattning I Skåne odlas 34 500 ha sockerbetor för sockerutvinning och i Sverige 36 000 ha (Jordbruksstatistik årsbok 2014). Vid insamling och rötning av blasten från betorna i Skåne skulle drygt 200 GWh biogas kunna produceras per år och driva minst 19 000 bilar eller 1000 bussar. Men idag lämnas den i fält. Tidigare studier har visat att betblast från sockerproduktion är på gränsen till löns
Aim: Solid tumours constitute 40% of childhood malignancies. The Swedish Childhood Cancer Registry is population-based and includes all children with cancer reported from the six paediatric oncology centres in Sweden. The aim was to investigate incidence and survival. Methods: We used the new WHO ICCC-3 for reclassification of the patients. Incidence and survival analyses were performed in the stu
