Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 interventio

Although meta-analyses of genome-wide association studies have identified more than 60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information whether these variants also affect α-cell function. The aim of the present study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We st

We study the induced subgraph isomorphism problem and the general subgraph isomorphism problem for small pattern graphs. We present a new general method for detecting induced subgraphs of a host graph isomorphic to a fixed pattern graph by reduction to polynomial testing for non-identity with zero over a field of finite characteristic. It yields new upper time bounds for several pattern graphs on

The Matern covariance function is a popular choice for modeling dependence in spatial environmental data. Standard Matern covariance models are, however, often computationally infeasible for large data sets. Recent results for Markov approximations of Gaussian Matern fields based on Hilbert space approximations are extended using wavelet basis functions. Using a simulation-based study, these Marko

Propionic acid was produced from glycerol using Propionibacterium acidipropionici. In this study, the impact of the concentrations of carbon and nitrogen sources, and of different modes of high cell density fermentations on process kinetics and -efficiency was investigated. Three-way ANOVA analysis and batch cultivations at varying C/N ratios at pH 6.5 revealed that propionic acid production rate

AIM: To investigate serial serum concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in patients treated with mild hypothermia after cardiac arrest, and to study their association to severe infections, post cardiac arrest syndrome (PCAS) and long-term outcome. METHODS: Serum samples from cardiac arrest patients treated with mild hypothermia were collected serially at admission, 2, 6

Objective: This study evaluated the quality and readability of English-language internet information for adults with hearing impairment and their significant others. Design: Two keyword pairs (hearing loss and hearing aids) were entered into five country-specific versions of the most commonly used internet search engine in May 2011. Sample: For each of the 10 searches, the first 10 relevant websit

Abstract in UndeterminedSpatial data clearinghouses are one of the key features of a spatial data infrastructure (SDI). However, recent research indicates that few national clearinghouses function well, as the spatial data resources available cannot be satisfactorily accessed or optimally used. To improve the functionality, we propose that clearinghouses to be complemented with expert systems and

Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the rat

Perennial energy crop development is just starting in Poland and there are great expectations on this sector to make a substantial contribution to the achievement of renewable energy targets defined in the European Union (EU) directive 28/2009/EC. Insights into the economics of energy crop production may lead to a better understanding of the dynamics of developments in the field. This work address

Binary composite endpoints offer some advantages as a way to succinctly combine evidence from a number of related binary endpoints recorded in the same clinical trial into a single outcome. However, as some concerns about the clinical relevance as well as the interpretation of such composite endpoints have been raised, it is recommended to evaluate the composite endpoint jointly with the involved

Capsule The majority of Robins in Iberia are sedentary and stay in their nesting areas despite the pre- sumed increased competition that results from the seasonal flooding of the area by conspecific migrants. Aims To evaluate if Robins in Iberia are displaced from their nesting areas by the presence of large num- bers of competitors originating from higher latitudes. Methods Data from constant eff

Background: Potential fragrance allergens used in daily products should have a concentration limited to levels that are at, or below, acceptable exposure levels based on the quantitative risk assessment for the induction of dermal sensitization. To date, there are insufficient data to discern any quantitative relationship between induction and elicitation concentrations for fragrance ingredients

We wanted to investigate if plasma levels of antimicrobial polypeptides (AMPs) are increased in severe sepsis and if they correlate with severity and mortality. Samples were collected from 31 sepsis patients at the intensive care unit. The Sequential Organ Failure Assessment (SOFA) score and 90-day mortality were registered, and inflammatory markers and AMP levels were measured by ELISA. A median

Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 control

We report on recent new developments around the Astrometric Global Iterative Solution system. This includes the availability of an efficient Conjugate Gradient solver and the Generic Astrometric Calibration scheme that had been proposed a while ago. The number of primary stars to be included in the core solution is now believed to be significantly higher than the 100 Million that served as baselin