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The spin-echo spectrometer at the Spallation Neutron Source (SNS)

A novel neutron spin-echo spectrometer with superconducting main coils enabling enclosure by a double walled mu-metal magnetic shielding chamber has been built and set into operation at the spallation neutron source in Oak Ridge. The layout of the spectrometer is described. Performance with emphasis on the superconducting main solenoids and the time-of-flight operation is described. Data on resolu

Insulin Secretory Granules Enter a Highly Calcium-Sensitive State following Palmitate-Induced Dissociation from Calcium Channels: A Theoretical Study

Impaired insulin secretion is a major contributor to diabetes. Obesity is a known risk factor for the development of diabetes, and prolonged exposure of pancreatic islets to lipids results in impaired insulin secretion. Insulin is released from pancreatic beta-cells as a result of Ca2+-induced exocytosis. Recent experiments have shown that chronic palmitate exposure results in the loss of localise

Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: Part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA(2)LEN

Aims: To analyze the changes in the prevalence of asthma, bronchial hyperresponsiveness (BHR) and allergies in elite athletes over the past years, to review the specific pathogenetic features of these conditions and to make recommendations for their diagnosis. Mehtods: The Task Force reviewed present literature by searching Medline up to November 2006 for relevant papers by the search words: asthm

Essentialism or an Anthropological Approach: The Role and Function of the Scientific Study of Religion in a Historical Perspective

The study of religion has its historical origin in the confessional education of religious functionaries, which has influenced the structuring of the study. The order of the topics studied has been, as a rule, first, languages relevant for the study of the normative texts, then the interpretation of these texts, followed by the historical development within the religion, its doctrines (systematic

Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

Ollier disease and Maffucci syndrome are non-hereditary skeletal disorders characterized by multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci syndrome). We report somatic heterozygous mutations in IDH1 (c.394C>T encoding an R132C substitution and c.395G>A encoding an R132H substitution) or IDH2 (c.516G>C encoding R172S) in 87% of enchondromas (benign cartilage

Performance of Anisantha (Bromus) tectorum and Rumex acetosella in sandy calcareous soil

Many plants are adapted to an eroded landscape with a large proportion of virgin soil. Open and disturbed soils are today almost only restricted to agricultural fields with high loads of fertilizers. We conducted a pot experiment in order to investigate growth and nutritional constraints of one calcicole species, Anisantha (syn. Bromus) tectorum, and one calcifuge species, Rumex acetosella, in dec

Adaptive sequential Monte Carlo by means of mixture of experts

Appropriately designing the proposal kernel of particle filters is an issue of significant importance, since a bad choice may lead to deterioration of the particle sample and, consequently, waste of computational power. In this paper we introduce a novel algorithm adaptively approximating the so-called optimal proposal kernel by a mixture of integrated curved exponential distributions with logisti

Perioperative Haemorrhage in Endovascular Abdominal Aneurysm Repair Affects Outcome

Objective: This study aimed to evaluate the outcome and predisposing factors related to perioperative bleeding in patients treated with endovascular aneurysm repair (VAR) for ruptured and non-ruptured abdominal aortic aneurysm (AAA). Design: This was a retrospective cohort study. Methods: A total of 525 consecutive patients (73% elective) with AAA underwent EVAR at two vascular centres from 2008 t

Sick leave and disability pension among Swedish testicular cancer survivors according to clinical stage and treatment

Purpose. To investigate if testicular cancer survivors (TCSs) have a higher incidence of work loss compared with the population, accounting for stage, treatment and relapse.Material and methods. A cohort of 2146 Swedish TCSs diagnosed 1995-2007 (seminoma n = 926, non-seminoma n = 1220) was identified in the SWENOTECA (Swedish-Norwegian Testicular Cancer Group) register, and matched 1:4 to populati

Supporting roadmapping of quality requirements

Would slightly better performance be significantly more valuable from a market perspective? Would significantly better performance be just slightly more expensive to implement? When dealing with performance, usability, reliability, and so on, you often end up in difficult trade-off analysis. You must take into account aspects such as release targets, end-user experience, and business opportunities

Measurement of dijet k(T) in p-Pb collisions at root s(NN)=5.02 TeV

A measurement of dijet correlations in p-Pb collisions at root s(NN) = 5.02 TeV with the ALICE detector is presented. Jets are reconstructed from charged particles measured in the central tracking detectors and neutral energy deposited in the electromagnetic calorimeter. The transverse momentum of the full jet (clustered from charged and neutral constituents) and charged jet (clustered from charge

Validation in Swedish of sydney swallow questionnaire.

The aim of this study was to translate and adapt the Sydney Swallow Questionnaire to Swedish conditions and to evaluate the validity and test-retest reliability of the Swedish translation in patients with oropharyngeal dysphagia and in healthy controls.

Synergistic effects of mesenchymal stromal cells and immunotherapy in experimental brain tumors

Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain tumor. In spite of surgical resection, combined radiation therapy and chemotherapy, the mean survival is less than 15 months following diagnosis. Using the established N29 and N32 animal models of glioma, shown to have many similarities with the human tumor, we are able to study and develop therapeutic strategies

Karyological and endosymbiotic notes on two Choricystis species (Trebouxiophyceae, Chlorophyta)

Two species of the genus Choricystis (Choricystis minor and Choricystis chodatii) have been chromosomally surveyed. In addition, their ability to form symbiotic associations with the ciliate Paramecium bursaria was also investigated. Choricystis minor (clone #8931/1 from strain #8931) was isolated from a moss sample collected on Livingston Island, Maritime Antarctica. Choricystis chodatii (clone #

Devising renewable heat policy: Overview of support options

Renewable energy sources of heat offer the substantial economic, environmental and social benefits associated with renewable electricity but policy to support their expansion is considerably less advanced. The potential for applying various support instruments to renewable heat is considered with advantages and disadvantages discussed. (c) 2012 Published by Elsevier Ltd.

Neurocognitive test profiles of extremely low birth weight five-year-old children differ according to neuromotor status

The neurocognitive outcome of children born with extremely low birth weight (ELBW) is highly variable due to the complexity of morbidity. So far, no study has compared comprehensive neuropsychological test profiles in groups with different neuromotor status. In a national cohort of ELBW children neuropsychological test profiles were assessed in 4 groups defined according to a neurological examinat

The impact of nocturnal CPAP-treatment on sexuality and closeness in patients with obstructive sleep apnea.

Sleep has a major impact on our wellbeing and how we perform.OSA has an estimated prevalence of 2 % in women and 4 % in male and is characterized by repetitive complete (apnoea) or partial (hypopnoea) cessation of breathing. I wondered how the patients managed sexuality and closeness when suffering from OSA and in particular how the Continuous Positive Airways Pressure (CPAP) treatment affected th