Amyloid fibrils may adopt different morphologies depending on the solution conditions and the protein sequence. Here, we show that two chemically identical but morphologically distinct α-synuclein fibrils can form under identical conditions. This was observed by nuclear magnetic resonance (NMR), circular dichroism (CD), and fluorescence spectroscopy, as well as by cryo-transmission electron micros

Background: C-type natriuretic peptide (CNP) is a known target for promoting growth and has been implicated as a therapeutic opportunity for the prevention and treatment of cardiovascular disease (CVD). This study aimed to explore the effect of CNP on CVD risk using the Mendelian randomization (MR) framework. Methods: Instrumental variables mimicking the effects of pharmacological intervention on

Control of crop pests by shifting host plant availability and natural enemy activity at landscape scales has great potential to enhance the sustainability of agriculture. However, mainstreaming natural pest control requires improved understanding of how its benefits can be realized across a variety of agroecologies. Empirical studies suggest significant but highly variable responses of natural pes

I Norge ble en ny modell for beregning av nettleie innført 1. juli 2022. Formålet med den nye nettleien er å motivere husholdninger til å fordele strømforbruket jevnere utover døgnet. På tidspunktet hvor den nye nettleien ble planlagt innført var det liten kunnskap om virkninger av slike virkemidler på forbrukere. Flexeffect-prosjektet startet har undersøkt virkninger virkemidler for fleksibel st

ObjectivesAn endovascular aneurysm repair (EVAR) graft is a catheter-implanted vascular prosthesis and is the preferred treatment for patients with aortic aneurysm. If an EVAR graft becomes the focus of infection, the treatment possibilities are limited as it is technically difficult to remove the graft to obtain source control. This study examines whether Pseudomonas aeruginosa and Staphylococcus

So called ‘smart’ built environments operate in a peculiar temporal nexus: they are simultaneously just around the corner, already here, and yesterday’s news. This is usually put down to hype and hyperbole, but it may well be argued that smart built environments do indeed exist across temporal dimensions – only not in the way we imagine them to.Instead of speaking of a digital turn in housing, we

Prediction of analyte retention times requires prior knowledge of the column void volume, the measurement of which is still highly contested within the literature and therefore experimental based prediction is often used. In this study, we investigated deuterated acetonitrile as an isotopically labelled mobile phase component to observe its elution behaviour in a binary mixture with water at 25 di

The suitability of Hansen solubility parameters as descriptors for modelling analyte retention during reversed-phase chromatographic experiments was investigated. A novel theoretical model using Hansen solubility parameters as the basis for a complete mathematical derivation of the model was developed. The theoretical model also includes the cavitation volumes of the analytes, which were calculate

Non-destructive spectroscopic analysis combined with machine learning rapidly provides information on the identity and content of plasticizers in PVC objects of heritage value. For the first time, a large and diverse collection of more than 100 PVC objects in different degradation stages and of diverse chemical compositions was analysed by chromatographic and spectroscopic techniques to create a d

https://lubcat.lub.lu.se/cgi-bin/koha/opac-detail.pl?biblionumber=2591569

OBJECTIVES: Our objective was to characterize longitudinal patterns of viraemia and factors associated with viral suppression in people with HIV and low-level viraemia (LLV) during antiretroviral therapy (ART).METHODS: We included people with HIV in the EuResist Integrated Database with LLV following ART initiation after 2005. LLV was defined as two or more consecutive viral load (VL) measurements

The aTfaRel2/faRel2 operon from Coprobacillus sp. D7 encodes a bicistronic type II toxin-antitoxin (TA) module. The FaRel2 toxin is a toxic small alarmone synthetase (toxSAS) that inhibits translation through the pyrophosphorylation of uncharged tRNAs at the 3'-CCA end. The toxin is neutralized by the antitoxin ATfaRel2 through the formation of an inactive TA complex. Here, the production, biophys

Föreliggande rapport syftar till att översiktligt rapportera resultaten från forskningsprojektet CYNKA: Kombinerad mobilitet mellan cykel och kollektivtrafik för regional Arbetspendling. Rapporten sammanfattar de olika delar som utgjort projektet som pågått under perioden 2019–2022.Tidigt i projektet genomfördes en litteraturstudie (K2 Working Paper 2021:15). Den visade bland annat att en välfunge

"The Sixties." The powerful images conveyed by those two words have become an enduring part of American cultural and political history. But where did Sixties radicalism come from? Who planted the intellectual seeds that brought it into being? These questions are answered with striking clarity in Andrew Jamison and Ron Eyerman's book. The result is a combination of history and biography that vividl

Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy of chronic lymphocytic leukemia (CLL), but continuous therapy has been complicated by the development of resistance. The most common resistance mechanism in patients whose disease progresses on covalent BTK inhibitors (BTKis) is a mutation in the BTK 481 cysteine residue to which the inhibitors bind covalently. Pirtob

The characterisation of fast phenomena at the microscopic scale is required for the understanding of catastrophic responses of materials to loads and shocks, the processing of materials by optical or mechanical means, the processes involved in many key technologies such as additive manufacturing and microfluidics, and the mixing of fuels in combustion. Such processes are usually stochastic in natu