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A systematic overview of radiation therapy effects in skeletal metastases

A systematic review of radiation therapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for skeletal metastases is based on data from 16 randomized trials. Moreov

Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region

Seventeen ETV6/RUNX1-positive pediatric acute lymphoblastic leukemias were investigated by high-resolution array-based comparative genomic hybridization ( array CGH), gene expression profiling and fluorescence in situ hybridization. Comparing the array CGH and gene expression patterns revealed that genomic imbalances conferred a great impact on the expression of genes in the affected regions. The

Biodiversity, distributions and adaptations of arctic species in the context of environmental change

The individual of a species is the basic unit which responds to climate and UV-B changes, and it responds over a wide range of time scales. The diversity of animal, plant and microbial species appears to be low in the Arctic, and decreases from the boreal forests to the polar deserts of the extreme North but primitive species are particularly abundant. This latitudinal decline is associated with a

Base-catalyzed intramolecular condensation of tokinolide B.

The novel pentacyclic compound cyclotokinolide B was obtained from the natural phthalide tokinolide B under basic conditions, via the chemoselective -enol lactone opening followed by a Michael addition of the generated carbanion to the enone and subsequent equilibration. This result confirms that some dimeric phthalides undergo intramolecular cyclizations in basic media.

Att bo med soffa : en möbels betydelse för bostadens planering och livet i hemmet

Popular Abstract in Swedish Soffan är en stor och vanligt förekommande möbel. Hur viktig den är blir särskilt tydligt när människor själva planerar sina bostäder och ekonomin styr bostadens storlek. Erfarenheter från tre projekt med brukarinflytande i bostadsplanering ligger till grund för det här avhandlingsarbetet. I samtal kring soffan visar det sig att den är intimt förknippad med värderingar Experiences of participatory design with full-scale modelling in three case studies form the basis of this work. When the participants in these studies visualised their dwellings there was a strong focus on the sofa. This piece of furniture is one of the most common in Swedish homes. It also requires much space. Additionally, the lay-people focused on different kinds of functional needs while sitt

Al-26 at the AMS facility in Lund

To broaden the AMS programme in Lund by including Al studies, a new injector has been installed and tested at the 3 MV Pelletron accelerator. Detailed optical calculations have been performed to obtain maximum mass and energy resolution. The design of the injector, the improvement in the resolution compared to the old injector, as well as preliminary tests with a Al-26-beam, are presented. By usin

Hydration of trimethylamine-N-oxide and of dimethyldodecylamine-N-oxide: An ab initio study

Density functional theory (B3LYP) calculations of the hydration of trimethylamine-N-oxide (TMAO) and a surfactant dimethyldodecylamine-N-oxide (DDAO) are reported. Hydrogen-bonded complexes of DDAO with up to three water molecules and of TMAO with up to five water molecules are studied. Interactions of both TMAO and DDAO with water give rise to the binding energies that are much higher than that i

Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis

Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chon

Acute contractile effects of epidermal growth factor on bladder smooth muscles. An in vivo and in vitro study in rats

Chronic treatment with epidermal growth factor (EGF) stimulates growth of all wall layers of the urinary tract in pigs and rats. Herein, we investigated the acute effects of EGF on detrusor smooth muscle activity. For in vivo examination, awake rats received EGF (75 micrograms/kg) intravenously and detrusor smooth muscle activity was monitored cystometrically. The EGF bolus caused no alteration in

Influence of lifestyle behaviours on bone mineral density among young healthy women: A two-year study. A Tentative Salutary Model.

Popular Abstract in Swedish Skeletthälsa och livsstilsbeteenden hos unga kvinnor I Sverige kommer ungefär 50 % av alla kvinnor att drabbas av en fraktur någon gång under sitt liv. Ett starkt skelett med hög mängd benmassa är det som främst bidrar till att förebygga benskörhetsfrakturer. Kvinnor har efter ungdomsåren mindre mängd benmassa än män och mängden benmassa minskar hos kvinnor snabbare i The overall aim of this prospective observational study with a salutogenic approach was to investigate bone mineral density (BMD) and BMD changes in the heel bone, in a group of healthy women, in relation to physiological factors and lifestyle behaviours over a two-year period as well as investigating the women’s view of their lifestyle behaviours. Data were collected in 1999 (T1) and 2001 (T2). H