Islet dysfunction is central in type 2 diabetes and full-blown type 2 diabetes develops first when the beta cells lose their ability to secrete adequate amounts of insulin in response to raised plasma glucose. Several mechanisms behind beta cell dysfunction have been put forward but many important questions still remain. Furthermore, our understanding of the contribution of each islet cell type in

Background: Sex chromosomes have evolved numerous times, as revealed by recent genomic studies. However, large gaps in our knowledge of sex chromosome diversity across the tree of life remain. Filling these gaps, through the study of novel species, is crucial for improved understanding of why and how sex chromosomes evolve. Characterization of sex chromosomes in already well-studied organisms is a

Fully localised three-dimensional solitary waves are steady water waves which are evanescent in every horizontal direction. Existence theories for fully localised three-dimensional solitary waves on water of finite depth have recently been published, and in this paper we establish their existence on deep water. The governing equations are reduced to a perturbation of the two-dimensional nonlinear

The Solar System’s orbital structure is thought to have been sculpted by an episode of dynamical instability among the giant planets1–4. However, the instability trigger and timing have not been clearly established5–9. Hydrodynamical modelling has shown that while the Sun’s gaseous protoplanetary disk was present the giant planets migrated into a compact orbital configuration in a chain of resonan

The throughput of macromolecular X-ray crystallography experiments has surged over the last decade. This remarkable gain in efficiency has been facilitated by increases in the availability of high-intensity X-ray beams, (ultra)fast detectors and high degrees of automation. These developments have in turn spurred the development of several dedicated centers for crystal-based fragment screening whic

Background: Generalized pustular psoriasis (GPP) is a severe form of pustular psoriasis with generalized eruption of sterile pustules, often along with systemic symptoms. There is a scarcity of population-based estimates of GPP prevalence and incidence. Objectives: To estimate (i) the prevalence and incidence of GPP in the Swedish general population and (ii) the prevalence of psoriasis vulgaris wi

This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are aut

COVID-19 is the most immediate of several crises we face as human beings: crises that expose deeply-rooted matters of social injustice in our societies. Management scholars have not been encouraged to address the role that business, as we conduct it and consider it as scholars, has played in creating the crises and fostering the injustices our crises are laying bare. Contributors to this article d