Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive responses of cancer cells to hypoxia offers opportunities for tumour specific therapies. The aim of this

Cold weather garments are necessary for people who are exposed to cold environments (below -5 °C). The weight and bulkiness of such a cold weather clothing ensemble may limit human activity and reduce the productivity. In order to solve these problems, a slim garment with a built-in heating element could be useful. The heat input power and heating efficiency are the two most important parameters f

Abstract Aim: To test the hypothesis that there is a subgroup of children with attention deficit hyperactivity disorder (ADHD) who show a decline in ADHD-symptoms that is associated with signs of biological maturation, a phenomenon referred to as a 'maturation catch-up'. Methods: The parents of 147 children who were given an examination in grades one and two 1999-2000 that included assessment of A

This paper proposes an individualized approach to closed-loop control of depth of hypnosis during propofol anesthesia. The novelty of the paper lies in the individualization of the controller at the end of the induction phase of anesthesia, based on a patient model identified from the dose-response relationship during induction of anesthesia. The proposed approach is shown to be superior to admini

A list of the books in the library of the Danish queen Caroline Mathilde was compiled after her death in Celle, Germany, in 1775. The list is published and the contents of the libary analysed and discussed.

Genome sequencing can identify individuals in the general population who harbor rare coding variants in genes for Mendelian disorders1-7 and who may consequently have increased disease risk. Previous studies of rare variants in phenotypically extreme individuals display ascertainment bias and may demonstrate inflated effect-size estimates8-12. We sequenced seven genes for maturity-onset diabetes o

Synthetic gas (syngas) fuels are promising energy sources in the future. In the current work, laminar flame speeds of typical syngas with different H-2 contents were studied using both experimental measurements and kinetic simulations. Measurements were carried out using the Bunsen method with the flame area derived from the OH planar laser-induced fluorescence (OH-PLIF) images; while kinetic simu

Modern technology makes garments smart, which can help a wearer to manage in specific situations by improving the functionality of the garments. The personal heating garment (PHG) widens the operating temperature range of the garment and improves its protection against the cold. This paper describes several kinds of PHGs worldwide; their advantages and disadvantages are also addressed. Some challe

Educational software in which the student takes the role of teacher and instructs a digital tutee a so-called teachable agent has repeatedly proven to have positive effects for school children's learning. In a study with 39 preschoolers aged 3:9 to 6:3, we explored the conditions under which children this young would benefit as well from this kind of educational software. We specifically investiga

We report on synchrotron-based high-repetition rate ultrafast x-ray diffraction (UXRD) experiments monitoring the transport of heat from an epitaxial La0.7Sr0.3MnO3/SrTiO3 superlattice (SL) into the substrate on timescales from 100 ps to 4 mu s. Transient thermal lattice expansion was determined with an accuracy of 10(-7), corresponding to a sensitivity to temperature changes down to 0.01 K. We fo

The immobilization of functional biomolecules to surfaces is a critical process for the development of biosensors for disease diagnostics. In this work we report the patterned attachment of single chain fragment variable (scFv) antibodies to the surface of metal oxides by the photodeprotection of self-assembled monolayers, using near-UV light. The photodeprotection step alters the functionality at

we present results that provide fundamental insights on how to experimentally tailor the planar defect density and even the crystal structure in III-V metal-particle-seeded nanowires, where zinc blende is the stable bulk crystal structure. We have grown GaP nanowires with metal-organic vapor-phase epitaxy under different conditions: pulsing of the Ga source, and Continuous growth with and without

To present concept, methods and use of a knowledge database providing assessments of potential fetal risks for all drugs on the Swedish market. Assessments of fetal risks are made primarily by analyzing prospective epidemiological data from the Swedish Medical Birth Register on drug intake in relation to birth outcome. This is complemented by evaluation of the scientific literature. Following stan

During a few days at the end of November 1926, the Möllevången neighborhood in Malmö was the scene of violent confrontations between thousands of demonstrators and a large part of the city police force. Behind these demonstrations lay an industrial conflict, begun early in July that year at A. W. Nilsson factory. The workers went on strike, and a week or so later the factory owner employed a local

Aberrant expression of miR-96 in prostate cancer has previously been reported. However, the role and mechanism of action of miR-96 in prostate cancer has not been determined. In this study, the diagnostic and prognostic properties of miR-96 expression levels were investigated by qRT-PCR in two well documented prostate cancer cohorts. The miR-96 expression was found to be significantly higher in pr

Lead in blood is a major concept in biomonitoring of exposure but investigations of its alternatives are scarce. The aim of the study was to describe different lead biomarkers' variances, day-to-day and between individuals, estimating their fraction of the total variance. Repeated sampling of whole blood, plasma and urine were conducted for 48 lead-exposed men and 20 individuals under normal envir

Popular Abstract in Swedish Att mäta och beskriva självantändning vid förblandad kompressionsantändning (HCCI) HCCI-förbränning går ut på att luft och bränsle blandas, och komprimeras i en kolvmotor tills blandningen självantänder. På grund av den snabba förbränningen med det här konceptet förloras mindre värmeenergi, och verkningsgraden blir därför högre än för vanliga bensin- och dieselmotorer. HCCI is an advanced combustion concept, using premixed fuel and air with a diluted charge. This is thermodynamically favorable, leading to high efficiency and therefore lower CO2 emissions. The well-premixed and diluted fuel charge gives lower cylinder temperatures than conventional diesel compression ignition and spark ignited gasoline combustion, resulting in low engine out emissions of both nit

In the past, neutron imaging investigations have been mostly performed in "integrating mode", which averages over the full applied neutron energy spectrum. This article describes four different methods and devices of obtaining energy selectivity in the thermal to cold energy range, which allow a new approach in neutron imaging. Two principles have been used and tested: (a) selection of neutrons by