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Identification of the molecule(s) that globally induce a robust regenerative state in sensory neurons following peripheral nerve injury remains elusive. A potential candidate is brain-derived neurotrophic factor (BDNF), the sole neurotrophin upregulated in sensory neurons after peripheral nerve injury. Here we tested the hypothesis that BDNF plays a critical role in the regenerative response of ma
The charged-particle pseudorapidity density measured over four units of pseudorapidity in nonsingle-diffractive p + Pb collisions at a center-of-mass energy per nucleon pair root s(NN) = 5.02 TeV is presented. The average value at midrapidity is measured to be 16.81 +/- 0.71 (syst), which corresponds to 2.14 +/- 0.17 (syst) per participating nucleon, calculated with the Glauber model. This is 16%
Little is known of the population dynamics of long-range insect migrants, and it has been suggested that the annual journeys of billions of nonhardy insects to exploit temperate zones during summer represent a sink from which future generations seldom return (the “Pied Piper” effect). We combine data from entomological radars and ground-based light traps to show that annual migrations are highly a
An explorative study of factors affecting implementation and use of finance information systems (FISs) in developing countries is presented. The result is based on a field study investigating implementation of a finance information system at Makerere University, Uganda. Current literature suggests that how to implement information Systems (ISs) successfully is challenging, especially in developing
Ice in atmospheric clouds undergoes complex physical processes, interacting especially with radiation, which leads to serious impacts on global climate. After their primary production, atmospheric ice crystals multiply extensively by secondary processes. Here, it is shown that a mostly overlooked process of mechanical breakup of ice particles by ice-ice collisions contributes to such observed mult
We isolated and characterised 12 polymorphic microsatellite loci for the blue-tailed damselfly Ischnura elegans by screening a genomic library enriched for microsatellite motifs. The loci showed high variability for the number of alleles, and the expected and observed heterozygosities, and thus will be useful for future molecular studies. Cross-amplification in I. graellsii, I. ramburii and I. pum
The complement system is regulated by inhibitors such as factor I (FI), a serine protease that degrades activated complement factors C4b and C3b in the presence of specific cofactors. Mutations and polymorphisms in FI and its cofactors are associated with atypical hemolytic uremic syndrome (aHUS). All 14 complement factor I mutations associated with aHUS analyzed in this study were heterozygous an
Objective To explore whether a panel of kallikrein markers in blood: total, free and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2, could be used as a non-invasive alternative for predicting prostate cancer on biopsy in a screening setting. Subjects and Methods The study cohort comprised previously unscreened men who underwent sextant biopsy owing to elevated PSA (3 ng/
It is well-known that clay can form lamellar structures i.e. tactoids, and recently it has been shown that the tactoid formation is dependent on the platelet diameter. To the authors knowledge, no tactoid formation has been observed for montmorillonite platelets with a diameter less than 60nm. In this study, small angle X-ray scattering in combination with coarse-grained modeling and molecular dyn
Establishing a tractable yet complete reaction coordinate for the spin-state interconversion in d(4)-d(7) transition metal complexes is an integral aspect of controlling the dynamics that govern their functionality. For spin crossover phenomena, the limitations of a single-mode approximation that solely accounts for an isotropic increase in the metal-ligand bond length have long been recognized fo
Purpose The aim of this study was to find clinically relevant MIBG-avid metastatic patterns in patients with newly diagnosed stage 4 neuroblastoma. Methods Diagnostic I-123-MIBG scans from 249 patients (123 from a European and 126 from the COG cohort) were assessed for metastatic spread in 14 body segments and the form of the lesions: "focal" (clear margins distinguishable from adjacent background
This study investigated the relation between personality factors, as measured by the Swedish version of the NEO-FFI questionnaire, and the realism in older adults' (aged 60-93 years, n = 1,384) probability confidence judgements of their answers to general knowledge questions. The results showed very small effect sizes for the contribution of the personality variables to the fit between the proport
In the paper we present a research model for evaluating determinants of ERP value in small and medium-size enterprises (SMEs). The model is grounded in the diffusion of innovation (DOI) model and resource-based view of the firm (RBV) theory. The research model links six DOI determinants to explain ‘ERP use’ linked with two additional determinants to explain ‘ERP value’, on which nine hypotheses ar
We use classical density functional theory to investigate room temperature ionic liquid + solvent mixtures in porous electrodes. We consider those mixtures that display a miscibility gap in the bulk fluid and hence have the capacity to undergo capillary condensation in pores which preferentially attract the ionic liquid component. A novel aspect of this transition is that, when the system is at or
This study evaluates the agreement between echocardiographic and cardiac magnetic resonance (CMR) imaging data, and the impact a discrepancy between the two may have on the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC).
PURPOSE OF REVIEW: To describe the theory behind arterial waveform analysis, the different variables that may be obtained using this method, reliability of measurements and their clinical relevance. Areas for future research are identified. RECENT FINDINGS: The precision of cardiac output (CO) measurements varies considerably and deteriorates during haemodynamic instability. Significant device-to-
Introduction of a conjugated vaccine against encapsulated Haemophilus influenzae type b (Hib) has led to a dramatic reduction of invasive Hib disease. However, an increasing incidence of invasive disease by H. influenzae non-type b has recently been reported. Non-type b strains have been suggested to be opportunists in an invasive context, but information on clinical consequences and related medic
The characteristic striped appearance of zebras has provoked much speculation about its function and why the pattern has evolved, but experimental evidence is scarce. Here, we demonstrate that a zebra-striped horse model attracts far fewer horseflies (tabanids) than either homogeneous black, brown, grey or white equivalents. Such biting flies are prevalent across Africa and have considerable fitne
