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The demand for safe and durable modified-wood products is increasing in the construction sector. In this work, the in situ wet-chemistry synthesis of a glassy MgO/Na2O–SiO2 solid in Scots pine (Pinus sylvestris L.) sapwood via a two-stage impregnation process using an industrial timber-impregnation autoclave is reported. Magnesium sulphate heptahydrate (MgSO4·7H2O), a historic fire retardant, and

Rickard Länta är renskötare i Jåhkågasska sameby i den svenska delen av Sápmi. Hans renbetesmarker är starkt påverkade av projekt såsom skogsavverkning, vattenkraft, infrastrukturutveckling och turism. Därtill har det kontroversiella gruvprojektet i Gállok, som också är beläget i detta område, godkänts av den svenska regeringen och Högsta domstolen. Denna artikel bygger på ett samtal där Rickard bRickard Länta is a reindeer herder in Jåhkågasska reindeer herding community in Swedish administered Sápmi. The land in which his reindeer are migrating has already been impacted by projects such as deforestation, hydropower, infrastructure development, and tourism. In addition, the controversial Gállok mining project, which is also located in this land, has been approved by the Swedish government

Abstract INTRODUCTION Countries have varying, limited healthcare budgets for emerging disease-modifying therapies. Cost-effectiveness analysis, combined with country-level cost-effectiveness thresholds, can be used to estimate value-based prices (VBPs) for lecanemab and donanemab across 174 countries. METHODS The cost-effectiveness of lecanemab and donanemab was estimated using incremental cost an

In situ synthesis of oestrogens is of great importance in the development and progression of breast cancer. 17β-hydroxysteroid dehydrogenase (17HSD) type 2 catalyses oxidation from oestradiol to oestrone, and thereby protects the breast epithelial cells from oestradiol. Low expression of 17HSD type 2 has been associated with decreased survival in breast cancer, but no studies have investigated the

BACKGROUND AND PURPOSE: The breast cancer susceptibility genes BRCA1 and BRCA2 interact with Rad51, one of the central components in the homologous recombination repair pathway. This study evaluates the prognostic and predictive role of BRCA1, BRCA2 and Rad51, individually and as a complex, in breast cancer.MATERIALS AND METHODS: Expression of BRCA1, BRCA2 and Rad51 was investigated using immunohi

Female-producing parthenogenesis is widespread in stick insects. It ranges from rare in sexual species to facultative or obligate, the latter sometimes in hybrids. This review synthesizes current knowledge on its origins, mechanisms, and evolutionary consequences, highlighting the distinction between hybrid and intra-specific origins. Hybrid-derived parthenogens are rare, obligate, frequently poly

Background Severe exacerbations (SevEx), the typical endpoint when evaluating asthma therapies, may provide incomplete assessment, as it relies on patient perception of disease and physician action. CompEx, a composite outcome that includes SevEx and acute worsening events (AWEs) (evaluated from e-diary entries using deterioration in peak expiratory flow (PEF), reliever medication use and worsenin

This practice-based research employs sculptural and sound practices, and their mediation through representation, notation, technologies and performance, to develop an innovative compositional process named co-composition, in which physical and sonic material can be concurrently produced, rearranged and transformed.\nAt the core of this thesis is a multi-layered mode of thinking, informed by an und

Purpose: To investigate the expression and predictive role of the Mre11/Rad50/Nbs1 (MRN) complex and the ataxia-telangiectasia mutated protein (ATM) for the outcome of radiotherapy in breast cancer patients. Methods and Materials: The protein expression of ATM and the DNA repair proteins in the MRN complex were investigated using immunohistochemistry in tumors from 224 women with early breast canc

Purpose. Continuous minor steps of improvement in the management of breast cancer have resulted in decreased mortality rates during the last decades. The aim of this study was to compare the clinical outcome of patients with stage I breast cancer diagnosed during two time periods that differed with respect to adjuvant systemic therapy. Material and methods. The studied population consisted of all

Cyclin E and the retinoblastoma protein (Rb) are both important regulators of the G1 phase in the cell cycle. Overexpression of cyclin E and lost expression of Rb has previously been observed in breast tumours at frequencies of 10-50% and 20-30%, respectively. We explored the prognostic role of cyclin E and Rb in breast cancer patients randomised for tamoxifen (TAM), CMF (cyclophosphamide, metotre

The purpose was to study the prognostic and predictive roles of DNA protein kinase catalytic subunit (DNA-PKcs), Ku70/80 and p53 for the effect of radiotherapy in breast cancer patients. Protein expressions of Ku70/80, DNA-PKcs and p53 were examined using immunohistochemistry in tumours from 224 breast cancer patients, who were randomised to receive post-operative radiotherapy or adjuvant chemothe

BACKGROUND: Early HIV diagnosis allows timely interventions to control HIV transmission. We have determined the proportion of recent infections among people living with HIV (PLHIV) enrolling to care in Ethiopia and identified factors associated with recent infection. METHODS: Participants (aged ≥ 15 years) newly enrolled in HIV care were recruited from urban clinics in central Ethiopia (2022-2024)

Background: Adjuvant therapy of breast cancer patients reduces the risk of recurrence and mortality, although, a substantial proportion of patients acquire resistance and relapse in the disease. Predictors of therapeutic response are therefore important to avoid both therapy resistance and the side effects of inefficient regimes. The p53 protein is a key determinant to induce either growth arrest