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The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitocho
OBJECTIVE: While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortalit
We propose a low-scale renormalizable trinification theory that successfully explains the flavor hierarchies and neutrino puzzle in the Standard Model (SM), as well as provides a dark matter candidate and also contains the necessary means for efficient leptogenesis. The proposed theory is based on the trinification SU(3)C×SU(3)L×SU(3)R gauge symmetry, which is supplemented with an additional flavo
Hyperfine structure (HFS) measurements of neutron-rich iridium isotopes Ir196,197,198 (Z=77,N=119-121) were performed via in-gas-cell laser resonance ionization spectroscopy at the KEK Isotope Separation System. Magnetic dipole moments μ and isotope shifts were determined from the HFS spectra. The variation of mean-square charge radii and quadrupole deformation parameters of these isotopes were ev
Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential s
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the pathogenesis is not completely understood. The application of metabolomics could help in discovering new metabolic pathways involved in the development of the disease. Methods and Results We measured 112 baseline fasting metabolites of 3770 participants in the Malmö Diet and Cancer Study; these participants were fre
Bees exemplify flights under bright sunlight. A few species across bee families have evolved nocturnality, displaying remarkable adaptations to overcome limitations of their daylight-suited apposition eyes. Phase inversion to nocturnality in a minority of bees that co-exist with diurnal bees provides a unique opportunity to study ecological benefits that mediate total temporal niche shifts. While
Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pathways impinging on eIF4E, facilitates reshaping of proteomes without changes in abundance of corresponding mRNAs. Using polysome profiling developed
We identify earnings impacts of exposure to an infant health intervention in Sweden, using individual-linked administrative data to trace potential mechanisms. Leveraging quasi-random variation in eligibility, we estimate that exposure was associated with higher test scores in primary school for boys and girls. However, only girls were more likely to score in the top quintile. Subsequent gains, in
For the class of Hardy spaces and standard weighted Bergman spaces of the unit disk, we prove that the spectrum of a generalized Cesàro operator Tg is unchanged if the symbol g is perturbed to g+h by an analytic function h inducing a quasi-nilpotent operator Th, that is, spectrum of Th equals {0}. We also show that any Tg operator that can be approximated in the operator norm by an operator Th w
This thesis presents the study of a position-sensitive scintillation-based detector called the Solid-State Neutron Detector (SoNDe). SoNDe is being developed for cold- and thermal-neutron detection at the small-angle neutron scattering (SANS) instrument SKADI at the European Spallation Source (ESS), currently under construction in Lund, Sweden. The response of the detector scintillator, multi-anod
As an introduction to the rigorous treatment of diffusion encoding in the rest of the book, this chapter gives simple non-mathematical explanations of the relations between the properties of biological tissues and the translational motion of the tissue water with the aim of conveying an intuitive feel of the relevant time and length scales and the level of detail of the information that can be obt
Adiabatic laminar burning velocities and post-flame NO mole fractions for neat and blended ethanol and n-heptane premixed flames were experimentally determined using a heat flux burner and laser-induced fluorescence. The flames were stabilized at atmospheric pressure and at an initial temperature of 338 K, over equivalence ratios ranging from 0.6 to 1.5. These experiments are essential for the dev
Let S(Λ) denote the classical Littlewood–Paley operator formed with respect to a lacunary sequence Λ of positive integers. Motivated by a remark of Pichorides, we obtain sharp asymptotic estimates of the behaviour of the operator norm of S(Λ) from the analytic Hardy space HAp(T) to Lp(T) and of the behaviour of the Lp(T) → Lp(T) operator norm of S(Λ) (1 < p< 2) in terms of the ratio of the lacunar
It is known that for Kn,n equipped with i.i.d. exp (1) edge costs, the minimum total cost of a perfect matching converges to in probability. Similar convergence has been established for all edge cost distributions of pseudo-dimension . In this paper we extend those results to all real positive q, confirming the Mézard-Parisi conjecture in th
Study design: Cross-sectional and longitudinal. Objectives: To (i) describe health-related quality of life (HRQoL) and changes over 6 years in older adults aging with long-term spinal cord injury (SCI) and (ii) investigate how changes in HRQoL are associated with age, gender, and injury characteristics. Setting: Community in southern Sweden. Methods: From the initial 123 participants (years 2011–2
We document that a high level of natural productivity of the ocean - a rich bounty of the sea - has had a positive and persistent impact on economic development since pre-industrial times until today. In addition, we document that it is the bounty of the sea of the ancestors of current populations which drives the persistent effect, not geography per se. We argue that an explanation is that a rich
This paper studies the cultural causes and consequences of mass emigration from Scandinavia in the 19th century. I test the hypothesis that people with individualistic traits were more likely to emigrate, because they faced lower costs of leaving established social networks behind. Data from population censuses and passenger lists confirm this hypothesis. Children who grew up in households with no
Background: There is still a lack of knowledge regarding the natural course of resolution of hydronephrosis after pyeloplasty, and no consensus exists on how resolution of hydronephrosis is defined or when resolution is expected to occur. Objective: To determine when resolution of hydronephrosis occurs following pyeloplasty, by type of obstruction and by surgical approach. Methods: This retrospect
Peptide receptor radionuclide therapy is a type of molecular radiotherapy that has been used in the treatment of patients with neuroendocrine tumours for over two decades. It is not until recently, however, that it has achieved regulatory approval. The currently approved treatment regimen is a one-size-fits-all scheme, i.e. all patients receive a fixed activity of the radiopharmaceutical (177Lu-DO
