Background: After neoadjuvant chemotherapy (NAC), about 20% of pts with muscle-invasive UC are found to have advanced pT-stage or lymph node involvement and 5-year overall survival (OS) of them is < 30%. Tumor samples from these pts may provide information about chemotherapy resistance, and may predict for the activity of new drugs given postoperatively. Alterations of FGFR3 gene represent a thera

In this chapter, I seek to answer the following questions which guide this Nordicresearch project: What is the current state of knowledge on young women’s and men’s experiences of prostitution? Which social programmes address young women’s and men’s experiences of prostitution and what ideology informs these programmes? What is the legal environment in this context and how is it being implemented?

Background: Germ cell tumor patients with intermediate prognosis (IPGCT) according to the IGCCCG classification represent a heterogeneous group exhibiting a variety of clinical features. We established a registry to identify prognostic markers to further characterize IPGCT. Methods: A retrospective observational study was performed. Eligibility criteria were intermediate prognosis according to IG

Introduction: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Cyclooxygenase-2 (COX-2), which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (1

Over the past few decades, the automotive industry has increasingly looked towards increasing the efficiency of the internal combustion engine to meet more stringent emission norms and as a measure to meet demands for improved air quality in cities. One method to improve the internal combustion engine efficiency is to recover some of the energy lost to the coolant and the exhaust using a secondary

New nanomaterials are constantly developed with applications in everything from cosmetics to high tech electronics. Assessing their biological impact has been done by analysis of their adsorbed protein corona, in vitro cell assays, and larger scale ecotoxicological studies. This has proved to be a huge challenge due to the wide range of available nanomaterials and their unpredictable behaviour in

Semiconductor nanowires are increasingly used in optoelectronic devices. However, their effects on human health have not been assessed fully. Here, we investigate the effects of gallium phosphide nanowires on human lung adenocarcinoma cells. Four different geometries of nanowires were suspended in the cell culture for 48 hours. We show that cells internalize the nanowires and that the nanowires ha

The study of regional growth paths is a key theme in economic geography and of elemental interest for regional development. This paper addresses the interplay between path-dependent, structural forces and the construction and utilization of opportunities through agentic processes. Extending the evolutionary framework, it is argued that not only history but also perceived futures influence agentic

One important challenge of the wooden constructions is to achieve a high quality of acoustic insulation, especially decreasing the impact noise in the low-frequency range. In order to avoid over-designed solutions and expensive experimental tests in the design phase, reliable prediction tools are called for. This article is an initial investigation of modeling the ISO standardized tapping machine

Previous research has suggested that corporatist polities tend to enact more ambitious environmental policies than others. Here it is argued that the macro concept of corporatism can be dissected into three components: inclusiveness, consensualism and strength of tripartite organisations. These components of corporatism can be measured at the meso-level of policy networks. It is proposed that incl

Research on (verbo-) pictorial metaphors and other rhetorical figures is primarily focused on the genre of advertising, leaving other genres under-investigated. In this study, we focus on street art, a visually perceived cross-cultural medium used to address sociopolitical issues. This genre typically combines two interacting semiotic systems – language and depiction – and is thus a form of polyse

Background: Stored potato (Solanum tuberosum L.) tubers are sensitive to wet conditions that can cause rotting in long-term storage. To study the effect of water on the tuber surface during storage, microarray analysis, RNA-Seq profiling, qRT-PCR and phytohormone measurements were performed to study gene expression and hormone content in wet tubers incubated at two temperatures: 4 °C and 15 °C. Th

Conductive Electric Road Systems (ERS) appear as a promising solution for the electrification of transportation, particularly for heavy vehicles and long-distance trips but also for light vehicles. Significant research efforts are currently devoted to the development of conductive ERS systems, with up to four pilot test sites with different technologies in operation only in Sweden. With the help o

Only a few chronological constraints on Lateglacial and Early Holocene glacier variability in the westernmost Alps have hitherto been obtained. In this paper, moraines of two palaeoglaciers in the southern Écrins massif were mapped. The chronology of the stabilization of selected moraines was established through the use of 10Be cosmic ray exposure (CRE) dating. The equilibrium line altitude (ELA)

BACKGROUND: Patients with septic shock may undergo extensive physiological alterations that can alter antibiotic pharmacokinetics. OBJECTIVES: To describe the population pharmacokinetics of ciprofloxacin in septic shock and to define recommendations for effective ciprofloxacin dosing in these patients. METHODS: Adult patients with septic shock treated with ciprofloxacin were eligible for inclusion

Film clips, music, and self-referential statements (termed Velten, after their originator) have been successfully used to temporarily induce sadness and happiness. However, there is little research on the effectiveness of these procedures combined, particularly in internet-based settings, and whether Velten statements contribute to alter mood beyond the effect of simple instructions to close one’s

Declines in European farmland birds over past decades have been attributed to the combined effects of agricultural intensification and abandonment. Consequently, aspirations to stop declines should focus attention on reversing these changes through voluntary or policy-driven interventions. The design of such interventions should ideally be informed by scientific knowledge of which aspects of the t

Informal caregiving is increasingly considered a health care delivery-resource within the North European welfare states. While ‘informal’ often refers to non-professional, ‘caregiving’ connotes both affective concern (caring about) and practical action (caring for). This duality of meanings, however, often refers to the one direction in which care is given. Care, we suggest, is relational and also

This paper analyses the underlying reasons why innovators do not apply for trademarks for all of their valuable inventions. Using a unique database of UK innovations linked to innovative firms, the empirical analysis highlights the many ways that firms can alleviate information asymmetries and the constraints imposed by collaborative innovation without taking recourse to trademarks. When informati