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The function of alpha-cells in patients with type 2 diabetes is often disturbed; glucagon secretion is increased at hyperglycaemia, yet fails to respond to hypoglycaemia. A crucial mechanism behind the fine-tuned release of glucagon relies in the exocytotic machinery including SNARE proteins. Here, we aimed to investigate the temporal role of syntaxin 1A and SNAP-25 in mouse alpha-cell exocytosis.
Research on nutrient controls of planktonic productivity tends to focus on a few standard fractions of inorganic or total nitrogen (N) and phosphorus (P). However, there is a wide range in the degree to which land-derived dissolved organic nutrients can be assimilated by biota. Thus, in systems where such fractions form a majority of the macronutrient resource pool, including many boreal inland wa
The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be identified. The sequence was found to have bidirectional activity and is likely to regulate also RHBD
For functions. f is an element of L-1 (R-n) we consider extensions to R-n x R+ given by convolving f with an approximate identity. Fora large class of approximate identities we obtain a Fatou-type theorem where the convergence regions are sometimes effectively larger than the non-tangential ones. We then study a more restricted class of approximate identities for which the convergence regions are
This article discusses the advantages of the the Coherence Based Genealogical Method (CBGM), not only as a tool for reconstructing the text of the New Testament, but also for surveying the history of readings and for explaining textual changes. The CBGM promises to detect readings, which have emerged several times independently in the textual tradition. The method is applied to selected examples i
Background. Observational studies have suggested that BCG may have nonspecific beneficial effects on survival. Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG. Methods. In the period 2004-2008 we recruited 2320 LBW children in Bissau. The children were visited at home at 2, 6, and 12 months of a
A national study of BRCA1 and BRCA2 mutations in Danish HBOC (Hereditary Breast Ovarian Cancer) families revealed a total number of 322 mutation positive families, 206 (64%) BRCA1 and 116 (36%) BRCA2 positive families from a population of 5.5 million inhabitants. Seven hundred and twenty six mutation positive individuals were identified: 402 female BRCAl carriers, 79 male BRCAl carriers, 213 femal
The article tells the modern love story of the organic grower Eduardo and the people who savor his apples. One remarkable paradigm shift when it comes to contemporary food culture is that the product’s social, political and cultural entanglements are no longer hidden from view. This new context has created platforms where producers and consumer come together to co-produce. Here, I broaden the conc
Homonymous hemianopia (HH) is an anisotropic visual impairment characterized by the binocular inability to see one side of the visual field. Patients with HH often misperceive visual space. Here we investigated how HH affects visual motor control. Methods and Findings: Seven patients with complete HH and no neglect or cognitive decline and seven gender- and age-matched controls viewed displays in
The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by
High kinetic-energy photoelectron spectroscopy (HIKE) or hard x-ray photoelectron spectroscopy has been used to investigate the alloying of Ni/Cu (100) multilayers. Relative intensities of the corelevels and their chemical shifts derived from binding energy changes are shown to give precise information on physicochemical properties and quality of the buried layers. Interface roughening, including
Background: Knowledge about the relation between user involvement in the provision of assistive technology and outcomes of assistive technology use is a prerequisite for the development of efficient service delivery strategies. However, current knowledge is limited, particularly from low-income countries where affordability is an issue. The objective was therefore to explore the relation between o
Background: 112 patients who received small and medium sized St.Jude Regent heart valves (19-25 mm) at 7 Scandinavian centers were studied between January 2003 and February 2005 to obtain non-invasive data regarding the hemodynamic performance at rest and during Dobutamine stress echocardiography (DSE) testing one year after surgery. Material and methods: 46 woman and 66 men, aged 61.8 +/- 9.7 (18
We present an assessment of the barium abundance ratios for red giant member stars in the faint Hercules dwarf spheroidal (dSph) galaxy. Our results are drawn from intermediate-resolution FLAMES/GIRAFFE spectra around the Ba II 6141.71 angstrom absorption line at low signal-to-noise ratios. For three brighter stars we were able to gain estimates from direct equivalent-width measurements, while for
The neuropsychological network is a complex structure. To identify processes location and network capacity the brain imaging techniques together and in combination with other neuropsychological techniques and the expanding of well elaborated designs provide us with a multidimensional understanding, and contributes to the understanding of each illicit drug's character, which is of importance in des
Jordan has seen a large increase in inhabitants over the past five decades as a result of a high population growth rate and forced migrations. Economic and cultural development has improved the standard of living and changed consumer habits, resulting in an increase in the volume of municipal solid waste (MSW) over time. The rate of production of MSW has been estimated at about 1,964,284 ton annua
