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Petersén is head of the Huntington Disease Center and the clinical multi-professional HD team at the HD Clinic, located at the Neurology department at Skåne University Hospital (SUS) in Lund. The HD Center was formed at LU and Region Skåne with the aim to improve healthcare for families with HD and to bring research closer to the clinic. Please see www.huntingtoncentrum.se for more information. Th
https://www.huntington-research.lu.se/patients - 2025-08-01
Gabery S, Ahmed RA, Caga J, Kiernan MC, Halliday GM and Petersén Å. Neuropathology and Applied Neurobiology. 47(7): 979-989 (2021) doi.org/10.1111/nan.12709 Abstract Aims To determine the underlying cellular changes and clinical correlates associated with pathology of the hypothalamus in amyotrophic lateral sclerosis (ALS), as hypothalamic atrophy occurs in the preclinical phase of the disease.
Baldo B, Cheong RY, Petersén ÅPLoS One 9(10) (2014)AbstractPsychiatric and metabolic features appear several years before motor disturbances in the neurodegenerative Huntington’s disease (HD), caused by an expanded CAG repeat in the huntingtin (HTT) gene. Although the mechanisms leading to these aspects are unknown, dysfunction in the hypothalamus, a brain region controlling emotion and metabolism
Soylu-Kucharz R, Khoshnan A and Petersén Å. bioRxiv 2021.04.08.438894; First published April 9, 2021. https://doi.org/10.1101/2021.04.08.438894 Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, and underlying mechanisms are not fully known. As the IKKβ/NF
Henningsen JB, Soylu-Kucharz R, Björkqvist M and Petersén Å. Heliyon. 2021 Aug 14;7(8):e07808. doi: 10.1016/j.heliyon.2021.e07808. eCollection 2021 Aug. Abstract Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. T
https://www.huntington-research.lu.se/effects-excitotoxicity-hypothalamus-transgenic-mouse-models-huntington-disease - 2025-08-01
Learn more from these short films where Åsa Petersén talks about cognitive symptoms and behavioural changes and psychiatric in Huntington's disease. Published by courtesy of Riksförbundet Huntingtons Sjukdom. All films are in Swedish. To view the Swedish subtitles, please click the button "CC" in the control bar (third from right) and choose "Svenska". Åsa Petersén about cognitive symptoms. Åsa
https://www.huntington-research.lu.se/cognitive-symptoms-and-behavioural-changes - 2025-08-01
Gabery S, Kwa JE, Cheong RY, Baldo B, Ferrari Bardile C, Tan B, McLean C, Georgiou-Karistianis N, Poudel GR, Halliday G, Pouladi MA and Petersén Å. Acta Neuropathologica. 142(5): 791-806 (2021) doi: 10.1007/s00401-021-02362-8. Abstract Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. The typical motor symptoms have been a
https://www.huntington-research.lu.se/early-white-matter-pathology-fornix-limbic-system-huntington-disease - 2025-08-01
Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Petersén Å, Lindholm D and Korhonen L.Human Molecular Genetics 23: 5928-5939 (2014)AbstractHuntington's disease (HD) is an autosomal inherited neurological disease caused by a CAG repeat expansion in the first exon of huntingtin gene encoding for the huntingtin protein (Htt). In HD there is an accumulation of in
Dickson E, Soylu-Kucharz R , Petersén Å and Björkqvist M. Mol Metab. 2022 Mar;57:101439. doi: 10.1016/j.molmet.2022.101439. Epub 2022 Jan 7. Abstract Objective In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progress
Soylu-Kucharz R, Khoshnan A and Petersén Å. iScience 2022 Jan 19;25(2):103771. doi: 10.1016/j.isci.2022.103771. eCollection 2022 Feb 18. Abstract Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an
Dickson E, Sai Dwijesha A, Andersson N, Lundh S, Björkqvist M, Petersén Å and Soylu-Kucharz R. Frontiers in Neuroscience. 2022 Nov 3;16:1027269. doi: 10.3389/fnins.2022.1027269. PMID: 36408416; PMCID: PMC9671106. Abstract Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative diso
Petersén Å1 and Kirik D2.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Journal of Clinical Investigation 17:1-3 (2014)AbstractA common form of the hyperkinetic movement disor
https://www.huntington-research.lu.se/twisting-mice-move-dystonia-field-forward - 2025-08-01
Hellem MNN, Cheong RY, Tonetto S, Vinther-Jensen T, Hendel RK, Larsen IU, Nielsen TT, Hjermind LE, Vogel A, Budtz-Jørgensen E, Petersén Å and Nielsen JE. Parkinsonism and Related Disorders. 99: 23-29 (2022). Abstract Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social c
Bergh S, Cheong R Y, Petersén Å and Gabery S. Front. Mol. Neurosci., 14 September 2022; Sec. Molecular Signalling and Pathways; doi.org/10.3389/fnmol.2022.984317 Abstract Neurodegenerative disorders (NDDs) such as Huntington’s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable popu
Furby H, Moore S, Nordstroem A-L, Houghton R, Lambrelli D, Graham S, Svenningsson P and Petersén Å. Journal of Neurology. 270(2): 864-876 (2023) doi:10.1007/s00415-022-11418-y. Abstract Background: Huntington's disease (HD) is a rare, neurodegenerative disease and its complex motor, cognitive and psychiatric symptoms exert a lifelong clinical burden on both patients and their families. Objective:
https://www.regenerative-neurobiology.lu.se/news-0 - 2025-08-01
We are located in the Biomedical Center (BMC) in Lund in the south of Sweden. Our visiting address is Sölvegatan 17, building A11. How to get to Lund From Copenhagen airport: Copenhagen airport Kastrup (CPH) is Denmark's international airport, and is much closer to Lund than any other international airports.Here you have direct flights from & to Asia, America and most of the European countries.
https://www.regenerative-neurobiology.lu.se/visit-us - 2025-08-01
Major funding bodies supporting our research The Knut and Alice Wallenberg Foundation supports long-term, free basic research beneficial to Sweden, mainly in medicine, technology, and the natural sciences. This is achieved through long-term grants to excellent researchers and to projects. The Foundation can also initiate grants to strategic projects and scholarship programs. The Foundation has s
https://www.regenerative-neurobiology.lu.se/funding - 2025-08-01
Media appearance by year 20242024-05-08: Euronews: Parkinson’s patient moves freely again after world-first implant of lab-grown cells into his brain2024-05-06: SVT Play: Rapport 2024-05-062024-05-06: Dagens Nyheter: Nya celler i hjärnan hopp för patienter med Parkinsons sjukdom2024-01-23. The Stem Cell Podcast, Ep. 263: “ISSCR 2024: The Global Stem Cell Event” Featuring Drs. Amander Clark, Agnete
https://www.regenerative-neurobiology.lu.se/media-coverage - 2025-08-01
Parmar lab meetings during the fall/winter 2024 semester will take place in person at the A11 seminar room 13.00-14.30 on the following days:Nov 5Nov 12Nov 19Dec 2Dec 17Troubleshooting session will take place on:Nov 8 13-15Dec 6 13-15 Lund University - Grants Calendar Faculty of Medicine - Event Calendar
https://www.regenerative-neurobiology.lu.se/node/8/internal - 2025-08-01
