The hepatic catabolism of chylomicron remnants in normal rats and in hypothyroid rats which were either normocholesterolaemic or made hypercholesterolaemic by feeding cholesterol and cholic acid was studied in vivo and in hepatocyte monolayers. In vivo, the clearance of injected chylomicron remnants labelled with either cholesteryl- or retinyl ester was delayed in the hypercholesterolaemic hypothy

Diverse and complex interactions as well as multi-actor systems characterise resource use and re- source policy. This makes system analysis a relevant tool to orient resource policy towards the long term. Analysing such complex systems requires systemic thinking, consideration of causal loops as well as time-lags and delays in system responses.In the SimRess project, system analysis encompassed pa

WORLD6 model was developed and applied to simulate potential future supply and scarcity of a num- ber of natural resources within the system dynamics modelling workpackage of the SimRess project. The main objective of this report is to outline the overall structure of the WORLD6 model and provide a detailed description of the “resources” module implemented in the model.In the WORLD6 model, resourc

Report detailing activities and experiences related to the 2018-2019 Urban Creativity research theme at the Pufendorf Institute for Advanced Studies.

The effect of mild proteolytic treatment on chylomicron remnant uptake by rat hepatocyte monolayers was studied both at 4 degrees C and at 37 degrees C. At 4 degrees C binding of remnants to the cells was considerably lower than at 37 degrees C, and preincubation of the cells with pronase (2 micrograms/ml) further descreased binding of remnants at 4 degrees C by 63%. At 37 degrees C the effect of

1. Rat chylomicrons were labelled with 125I with 69--72% of the iodine in the protein moiety. Less than 1 nmol of iodine was incorporated per nmol of protein. Of the peptide radioactivity 44--56% was in apolipoprotein A-1, 30--40% in the C peptides and 11--15% in apolipoprotine B. The arginine-rich peptide, which accounted for about 14% of the chylomicron protein mass as determined by scanning of

1. The cholesteryl ester of isolated chylomicron-remnant particles was efficiently degraded by hepatocyte monolayers. The degradation was sensitive to metabolic inhibitors. 2. With increasing amounts of remnant cholesteryl ester the rate of uptake approached saturation and conformed to a linear double-reciprocal plot. The V(max.) was determined as 80ng of cholesteryl ester/h per mg of protein and

1. Hepatectomized rats were injected intravenously with doubly labelled ([14C]linoleic acid and [3H]palmitic acid) thoracic duct lymphs from rats fed cream, triolein or corn oil. The disappearance of the radioactive fatty acids of different molecular triacylglycerol species and of phospholipids from plasma was studied.2. 73–93% of the injected triacylglycerols had been cleared from plasma within 1