The novel wrought nickel-based superalloy, AD 730™, is a good candidate material for turbine disc applications at high temperatures beyond 650 °C. The present study focuses on the machining performance of this newly developed alloy under high-speed turning conditions with advanced PCBN tools. Meanwhile, the machined surface integrity as influenced by cutting speed and feed rate was also investigat

We report the measured transverse momentum (pT) spectra of primary charged particles from pp, p-Pb and Pb-Pb collisions at a center-of-mass energy sNN=5.02 TeV in the kinematic range of 0.15 < pT< 50 GeV/c and |η| < 0.8. A significant improvement of systematic uncertainties motivated the reanalysis of data in pp and Pb-Pb collisions at sNN=2.76 TeV, as well as in p-Pb collisions at sNN=5.02 TeV, w

A high-resolution chemostratigraphical (coupled δ13Ccarb and δ18Ocarb) study of the topmost Floian through the middle Darriwilian (Ordovician) succession at the Hällekis quarry, Kinnekulle, southern Sweden, shows relatively steady isotopic values with overall minor changes, although some notable short- and long-term shifts are discernible. A pronounced positive shift in δ13C in the uppermost part

Preparation of metal-halide perovskites under room temperature attracts attention because of energy saving by removing thermal annealing. Room-temperature transformation of spin-cast wet films consisting of methylammonium (MA) iodide, PbI2, and dimethylformamide toward solid MAPbI3 perovskite proceeds via several intermediate crystalline states and is strongly dependent on ambient humidity. Light

Immunophenotypic characterization and molecular analysis have long been used to delineate heterogeneity and define distinct cell populations. FACS is inherently a single-cell assay, however prior to molecular analysis, the target cells are often prospectively isolated in bulk, thereby losing single-cell resolution. Single-cell gene expression analysis provides a means to understand molecular diffe

Bacteria utilize complement regulators as a means of evading the host immune response. Here, we describe protocols for evaluating the role vitronectin acquisition at the bacterial cell surface plays in resistance to the host immune system. Flow cytometry experiments identified human plasma vitronectin as a ligand for the bacterial receptor outer membrane protein H of Haemophilus influenzae type f.

In the face of reduced public funding of science and increased demands for ‘value for money’, academic researchers find themselves hard pressed to produce relevant research and demonstrate their utility to society. These pressures are particularly prominent in the humanities and social sciences (HSS) where practical value is frequently questioned. This article investigates how HSS can be made ‘rel

From 2012 USA universities entered new partnerships with private sector companies including Silicon Valley start-up Coursera. Coursera spearheads a new broad online learning segment of the fast growing global ‘educational technology’ (EdTech) sector. They offered free ‘massive open online courses’ (MOOCs) for global, universal learner audiences. Since 2015 several USA universities and Coursera exp

Current EU policy calls for decreased emissions of greenhouse gases (GHG) by i.e., replacing fossil fuel in the transportation sector with sustainable biofuels. To avoid indirect land use change (iLUC), the EU at the same time strives to limit the use of crops and to increase the use of residues. In this study we compare climate impact and production cost for biogas and ethanol based on wheat grai

During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has beco

In recent years, the International Maritime Organization agreed on aiming to reduce shipping's greenhouse gas emissions by 50% with respect to 2009 levels. Meanwhile, cruise ship tourism is growing at a fast pace, making the challenge of achieving this goal even harder. The complexity of the energy system of these ships makes them of particular interest from an energy systems perspective. To illus

Exercise is associated with increased peak bone mineral density (BMD). To determine the relationship between the duration of exercise and BMD, we measured BMD of the axial and appendicular skeleton by dual-energy X-ray absorptiometry (DXA), and speed of sound (SOS), broadband attenuation (BUA), and stiffness index by quantitative ultrasound (QUS) of the calcaneus, in 67 active male national soccer

This prospective study evaluated bone loss in the peri- and postmenopausal period in 156 women followed from age 48 to 64 years. All women were premenopausal at the start of the study. Areal bone mineral density (g/cm2) was measured by single-photon absorptiometry (SPA) of the forearm at the 1 cm level (BMD 1 cm) and the 6 cm level (BMD 6 cm) every second year. Onset of menopause (MP) was determin

There has never been, and will never be, a randomized double-blind placebo-controlled trial demonstrating that exercise in youth, adulthood or old age reduces fragility or osteoporosis-related fractures in old age. The next level of evidence, a randomized, controlled but unblinded study with fractures as an end-point is feasible but has never been done. The basis for the belief that exercise reduc

No prospective randomized study with fracture as end point exists in men. Data from retrospective and prospective observational and case control studies suggest that activity in men is associated with reduced fracture risk. This may be correct, but consistently replicated sampling bias may produce the same observation, as these studies are hypothesis generating, never hypothesis testing. Higher mu

Men with spine fractures have reduced vertebral body (VB) volume and volumetric bone mineral density (vBMD). Men with hip fractures have reduced femoral neck (FN) volume and vBMD, site-specific deficits that may have their origins in growth. To describe the tempo of growth in regional bone size, bone mineral content (BMC), and vBMD, we measured bone length, periosteal and endocortical diameters, B

Skeletal development is heterogeneous. Throughout growth, bone size is more maturationally advanced than the mineral being accrued within its periosteal envelope; before puberty, appendicular growth is more rapid than axial growth; during puberty, appendicular growth slows and axial growth accelerates. We studied women with differing age of onset of anorexia nervosa to determine whether this tempo

Anorexia nervosa is associated with bone loss during adulthood, but may also delay skeletal growth and mineral accrual during growth. We asked the following questions. 1) Is anorexia nervosa associated with reduced bone size and reduced volumetric bone mineral density (vBMD)? 2) Is estrogen replacement therapy (ERT) or recovery from anorexia nervosa associated with normal bone size and vBMD? Using