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Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. Neuroblastoma is a childhood tumour that arises in the develop

Four kitchens, each with a different work load, were used to evaluate the microbiological risk of utilizing blasting granules in a new type of warewash machine. The granules, plastic pellets 3.5 - 3.5 mm, are recirculated together with the dishwater in the machine, and when the dishwater is expelled, the granules remain in the machine until the next day. Samples of soiled dishwater and tap water w

A method, based on the multiconfiguration Hartree-Fock approach, for ab initio calculations of Rydberg states has been developed. The method has been tested for a number of highly excited Rydberg states, with quantum numbers l = 4 - 8 and n <= 9, in Mg-like and Be-like ions. The results are compared with Hartree-Fock calculations to investigate the influence of correlation and, to a lesser extent,

Partial reduction of vanadia supported on silica-titania by NH3 + NO has been studied by electrical conductance and ESR measurements. The relationship between electrical conductance and degree of reduction was determined by oxidative and reductive titrations of V(IV) and V(V) species leached from catalyst samples which had been reduced to different levels. In situ monitoring of the steady-state V(

The aim of this report is to present some of the variable uncertainties associated with the dimensioning of fire protection in buildings and risk analysis in buildings (with respect to fire). A method for assessing the fire frequency in a building is presented along with examples of how the assessed fire frequency can be improved using fire data from a specific building. The probability of differe

Abstract is not available

A kinematic hardening plasticity model valid for finite strains is presented. The model is based on the well-known multiplicative split of the deformation gradient into elastic and plastic parts. The basic ingredient in the formulation is the introduction of a locally defined configuration-a centre configuration-which is associated with a deformation gradient that is used to characterize the kinem

To determine the impact of a family history of the common form of type 2 diabetes and the phenotype of the proband on anthropometric and metabolic variables in normoglycemic first degree relatives, we studied 2100 first degree relatives of patients with the common form of type 2 diabetes (FH+) and 388 subjects without a family history of diabetes (FH-). All subjects participated in an oral glucose

Indications of what the tour-operating sector considers to be 'good practice' can be drawn from voluntary initiatives such as existing eco-labels and codes of conduct. However, practical implementation of such guidance varies greatly from one tour operator to another, depending on different types of factors, such as size, financial capacity, corporate structure, operational location, organizationa

Popular Abstract in Swedish Tekniken för vitreoretinal kirurgi har utvecklats betydligt de senaste åren, både vad gäller metodik och instrumentering. Allt fler sjukdomstillstånd i näthinnan kan nu behandlas. För att utveckla dessa metoder vidare, och även öka kunskapen bakom verkningsmekanismen för deras effektivitet, är standardiserade djurmodeller där både funktion och histologi kan utvärderas aThe field of vitreoretinal surgery has expanded greatly over the last decades. A continuous refinement of surgical methods and instruments has increased the number of treatable retinal disorders. Vitrectomy, retinectomy and laser treatment are all part of the modern surgical arsenal. In order to further develop and refine these methods, and also to improve the knowledge of the mechanisms behind th