Characterising the interaction between cationic ionisable lipids (CIL) and nucleic acids (NAs) is key to understanding the process of RNA lipid nanoparticle (LNP) formation and release of NAs from LNPs. Here, we have used different surface techniques to reveal the effect of pH and NA type on the interaction with a model system of DOPC and the CIL DLin-MC3-DMA (MC3). At only 5% MC3, differences in

We present a novel class of minimax optimal control problems with positive dynamics, linear objective function and homogeneous constraints. The proposed problem class can be analyzed with dynamic programming and an explicit solution to the Bellman equation can be obtained, revealing that the optimal control policy (among all possible policies) is linear. This policy can in turn be computed through

Factors behind intraspecific variation in sensitivity to pathogens remain poorly understood. We investigated how geographical origin in two North European amphibians affects tolerance to infection by the chytrid fungus Batrachochytrium dendrobatidis (Bd), a generalist pathogen which has caused amphibian population declines worldwide. We exposed newly metamorphosed individuals of moor frog Rana arv

Aims: Infections are proposed risk factors for type 1 diabetes in children. We examined whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults (LADA). Materials and methods: We used data from a population-based Swedish case-control study with incident cases of LADA (n = 597) and matched controls (n = 2386). The history of infectious disease

We study a Dirichlet boundary problem related to the fractional Laplacian in a manifold. Its variational formulation arises in the study of magnitude, an invariant of compact metric spaces given by the reciprocal of the ground state energy. Using recent techniques developed for pseudodifferential boundary problems we discuss the structure of the solution operator and resulting properties of the ma

Cognitive decline in Alzheimer's disease and other dementias typically begins long before clinical impairment. Identifying people experiencing subclinical decline may facilitate earlier intervention. This study developed cognitive trajectory clusters using longitudinally based random slope and change point parameter estimates from a Preclinical Alzheimer's disease Cognitive Composite and examined

Sovereign is who decides; and who decides is responsible. The book develops these two arguments by comparing Carl Schmitt's and Dietrich Bonhoeffer's theories of sovereignty.Carl Schmitt was an influential jurist of Nazi Germany. Dietrich Bonhoeffer was a Lutheran priest hanged for his involvement in a plot to assassinate Adolf Hitler. In many ways, the two men could not be more different. But the

There are many pedagogical methods to engage students in active learning. This paper presents Discussion Seminars, which is one such method that is much appreciated by students. This paper explains how to structure seminars and discusses their benefits and what requirements they put on the teacher. The paper aims to inspire other teachers to try something similar.

Diffusion-weighted magnetic resonance imaging (DW-MRI) aims to disentangle multiple biological signal sources in each imaging voxel, enabling the computation of innovative maps of tissue microstructure. DW-MRI model development has been dominated by brain applications. More recently, advanced methods with high fidelity to histology are gaining momentum in other contexts, for example, in oncologica

Today, it is becoming increasingly common for companies to harness the spirit of play in order to increase worker engagement and improve organizational performance. This paper examines the ethics of play in a business context, focusing specifically on the phenomenon of workplace gamification. While critics highlight ethical problems with gamification, they also advocate for more positive, transfor

The polar format algorithm (PFA) is a popular choice for general bistatic synthetic aperture radar (BiSAR) imaging due to its computational efficiency and adaptability to situations with complicated geometries or arbitrary flight trajectories. However, efficient and accurate compensation of 2-D residual phase errors induced by the wavefront curvature remains challenging when obtaining high-quality

A Brain-Computer Interface (BCI) is a system that, in real-time, translates the user's brain activity into commands that can be used to control applications, such as moving a cursor on the screen. The translation is made possible by machine learning methods and other algorithms. The thesis focuses on EEG-based BCIs which are the most common type of BCIs due to EEG measurements being non-invasive,

Platinum-tin surfaces are active for CO oxidation, but their activity and the effects of tin oxide phases that form under reaction conditions are poorly understood. We have studied surface alloys of tin prepared on platinum single crystals during catalytic CO oxidation using near-ambient-pressure X-ray photoemission spectroscopy. On the flat terraces of Sn/Pt(111), a wetting layer of Sn(II) surfac

Background and purpose: Advances in characterizing cancer biology and the growing availability of novel targeted agents and immune therapeutics have significantly changed the prognosis of many patients with metastatic disease. Palliative radiotherapy needs to adapt to these developments. In this study, we summarize the available evidence for stereotactic body radiotherapy (SBRT) in the treatment o

The dominant road traffic particle sources are wear particles from the road and tire interface, and from vehicle brake pads. The aim of this work was to investigate the effect of road and brake wear particles on pulmonary function and biomarkers in isolated perfused rat lungs. Particles were sampled from the studded tire wear of three road pavements containing different rock materials in a road si