Sökresultat

Antisense oligonucleotides (ASO) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2'MOE) ASO have shown dose- A nd sequence-specific lowering of platelet counts according to two phenotypes. Phenotype 1 is a moderate (but not clinically severe) drop in platelet count. Phenotype 2 is rare, severe thrombocytopenia. This article focuses on the underlying cause of the mor

Health impact assessments (HIA) have largely focused on mortality; this report, therefore, examines and evaluates which morbidity impacts are appropriate to include in HIAs. The task was assigned by Swedish Environmental Protection Agency (EPA), and the original report (written in Swedish) was performed by Anna Oudin (AO), Erin Flanagan (EF), and Ebba Malmqvist (EM). The original report also inclu

Background: Primary graft dysfunction (PGD) is still a major complication in patients undergoing lung transplantation (LTx). Much is unknown about the effect of postoperative mechanical ventilation on outcomes, with debate on the best approach to ventilation. Aim/Purpose: The goal of this study was to generate hypotheses on the association between postoperative mechanical ventilation settings and

Den här artikeln handlar om hur några palestinska nyanlända upplevde Etableringsprogrammet som ett hinder för integration. Trots ett fokus på rättigheter, gratis svenskundervisning och riktade program verkar alltför många människor som flyr till Sverige fastna i fattigdom och arbetslöshet. Alla drömmar och förhoppningar flyktingar hade med sig från sina tidigare liv verkar så obegripligt svåra att

Although e-scooter sharing has become increasingly attractive, little attention has been paid to a comprehensive comparison of e-scooter sharing mobility in multiple cities. To fill this gap, we conduct a comparative study to reveal the similarity and difference of e-scooter sharing mobility by collecting and analyzing vehicle availability data from 30 European cities during post COVID-19 pandemic

There is a large body of scientific evidence on the climate crisis and flooding in urban areas. Extreme weather events are producing extensive property damage and loss of life and require new modes of flood governance. However, the climate crisis does not stop at the city limits: peri-urban areas have related but distinct flood challenges due to land use change, regulation, perceptions, and capaci

In this work we construct explicit complex-valued p-harmonic functions on the compact Riemannian symmetric spaces SU(n)/SO(n), Sp(n)/U(n), SO(2n)/U(n), SU(2n)/Sp(n). We also describe how the same can be manufactured on their non-compact symmetric dual spaces.

Calcium sulfate/hydroxyapatite (CaS/HA) biomaterials have been investigated for use in several orthopedic applications. However, the mechanical interactions between the composite of CaS/HA and bone at the microscale are still unknown. The aim of this study was to determine if and how augmentation with CaS/HA alters the fracture behavior of bone. Eleven cylinders of trabecular bone were drilled fro

BACKGROUND: The ABO and RhD blood group represent antigens on the surface of erythrocytes. The ABO blood group antigens are also present on multiple other cells. Interestingly, previous studies have demonstrated associations between the blood group and many types of disease. The present study aimed to identifying associations between the ABO blood group, the RhD blood group, and morbidity and mort

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

Wetland bird species have been declining in population size worldwide as climate warming and land-use change affect their suitable habitats. We used species distribution models (SDMs) to predict changes in range dynamics for 64 non-passerine wetland birds breeding in Europe, including range size, position of centroid, and margins. We fitted the SDMs with data collected for the first European Breed

Bacteria in the order 'Candidatus Brocadiales' within the phylum Planctomycetes (Planctomycetota) have the remarkable ability to perform anaerobic ammonium oxidation (anammox). Two families of anammox bacteria with different biogeographical distributions have been reported, marine Ca. Scalinduaceae and freshwater Ca. Brocadiaceae. Here we report evidence of three new species within a novel genus a

Människobehandlande yrken, såsom socialt arbete, syftar till att identifiera och åtgärda problem i människors liv. Hur skapas en förståelse av vad ett problem innebär? Hur nås enighet i fall där det finns flera motstridande definitioner och förklaringar till vad som ska anses vara problematisk? Detta kapitel handlar om hur en förståelse av ett problem och lösningar på det kan skapas i ett möte melMänniskobehandlande yrken, såsom socialt arbete, syftar till att identifiera och åtgärda problem i människors liv. Hur skapas en förståelse av vad ett problem innebär? Hur nås enighet i fall där det finns flera motstridande definitioner och förklaringar till vad som ska anses vara problematisk? Detta kapitel handlar om hur en förståelse av ett problem och lösningar på det kan skapas i ett möte mel

I detta kapitel undersöker vi några av de frågor som uppstår när mötet med klienten är begränsat till de skrivna orden. Hur visar man sin närvaro när man inte ser varandra? Hur förmedlar man förståelse och stöd i en textbaserad dialog? Vi går igenom skillnader mellan stödjande samtal i det fysiska rummet och textbaserat stöd på internet. Utifrån tidigare forskning och exempel från en chatt, som erI detta kapitel undersöker vi några av de frågor som uppstår när mötet med klienten är begränsat till de skrivna orden. Hur visar man sin närvaro när man inte ser varandra? Hur förmedlar man förståelse och stöd i en textbaserad dialog? Vi går igenom skillnader mellan stödjande samtal i det fysiska rummet och textbaserat stöd på internet. Utifrån tidigare forskning och exempel från en chatt, som er

Starch is the most abundant component in wheat flour, but has not traditionally been regarded as responsible for differences in quality between wheat varieties. In this chapter the role of starch in the baking process is described and examples on the role of starch during mixing, fermentation, and the oven step are given. The relevance of starch for baking performance is discussed, e.g., the setti

Nanoporous metals fabricated by dealloying have a unique bi-continuous, sponge-like porous structure with ultra-high surface area. The unique properties of these materials, especially nanoporous gold, have numerous potential applications in sensors and actuators and in energy-related applications such as catalytic materials, super-capacitors, and battery supports. The degree of porosity and size o