The process of becoming an Ig-producing plasma cell takes the mature B cell through the germinal center, where Ig genes are diversified through somatic hypermutation and class switch recombination. To more clearly define functional characteristics of the germinal center dark zone centroblasts and the light zone centrocytes, we have performed expression analysis of the CD77(+) and CD77(-) populatio

Objective: The aim of this study was to test the feasibility and accuracy of transthoracic Doppler echocardiography measurement of coronary flow reserve (CFR) in the left anterior descending coronary artery (LAD) territory in the clinical setting of the acute coronary syndrome. Methods: Transthoracic Doppler echocardiography measurements of CFR were made in 42 consecutive patients in the distal LA

Strong superlattice effects are reported on E(k(vertical bar vertical bar)) band dispersions measured by angle-resolved photoemission on W(3 3 1) and W(5 5 1), and graphene nanostripes on Ni(7 7 1). A splitting of the dispersions with reciprocal superlattice vector G = 2 pi/L is observed for a surface resonance on W(3 3 1) and W(5 5 1) and for pi-states of graphene/Ni(7 7 1). Photon-energy-depende

Huntington's disease is an autosomal dominant neurodegenerative disorder caused by an expanded CAG repeat. It is characterized by motor and cognitive disturbances, as well as cellular dysfunction and loss in the basal ganglia and the cerebral cortex. The mutant protein huntingtin aggregates in cells. The toxicity of mutant huntingtin, or the loss of its normal function, causes disruption of cellul

Using the particle-rotor model in which one high-j quasiparticle is coupled to the core of triaxial shape, wobbling excitations are studied. The family of wobbling phonon excitations can be characterized by: (a) very similar intrinsic structure while collective rotation shows the wobbling feature; (b) strong B(E2;I-->I-1) values for Deltan(w)=1 transitions where n(w) expresses the number of wobbli

Artikeln behandlar muralmålningarna i Borgmästarehuset i Ystad, som 1907 demonterades och flyttades till museiområdet i staden. De kan av förfataren med hjälp av fotografisk dokumentation beläggas på samma plats före rivningen, och de dateras med hjälp av träsnitt som kan ha fungerat som förlagor till 1500-talets senare del. Deras ikonografi, kring Kristi passionshistoria, och deras funktion i en

The adaptation of three allopatric populations of a generalist moth, Operophtera brumata (L.), on two tree species, Prunus padus (L.) and Quercus robur (L.) which represent the extremes of the timing of budburst in spring, was studied in Finland and Sweden. The synchrony of the hatching and budbursting was monitored, and its importance to dispersal and growth of larvae was assessed by rearing coho

1. The combination of interleukin-2 (IL-2) and IL-4 reduces the inhibitory effects of glucocorticoids on granulocyte-macrophage colony-stimulating factor (GM-CSF) production, in agreement with the hypothesis that this combination causes glucocorticoid resistance. Whether a general cytokine resistance to glucocorticoids is induced by IL-2 and IL-4 has not been reported. 2. Mononuclear blood cells f

Silicone tubes of appropriate sizes were used to enclose the injured zone of transsected ulnar and median nerves in the human forearm as an alternative to conventional microsurgical repair of the nerve trunk. A gap measuring 3-5 mm was left intentionally between the nerve ends inside the tube. The clinical early results from a prospective randomised study that compared these two principles have re

Since many years, life charting has been used to describe the life course and life events of psychiatric patients. The aim of the present study was to describe and evaluate time geographic life. charts of 11 former psychiatric patients in order to promote systematic descriptions of their life events over time. Information on all events which was gathered from the life charts was analysed by manife

Pseudoneurological symptoms (i.e., conversion disorder), historically subsumed within the "hysteria" concept alongside phenomena such as psychogenic amnesia and multiple personality disorder have been classified as somatoform disorders since DSM-III. Since then, there have been repeated calls to reclassify conversion disorder with the dissociative disorders, as in ICD-10. The authors review issues

Popular Abstract in Swedish Allt fler marknads- och teknikdrivna programvarutvecklingsföretag ställs inför utmaningen att hantera tusentals krav som uttrycks i vanlig textuell form. Det stora antalet krav orsakar flaskhalsar i kravhanteringsprocessen vilket påkallar en mer effektiv kravhantering. Denna avhandling presenterar resultaten från empiriska undersökningar av att använda språkvetenskapliAn increasing number of market- and technology-driven software development companies face the challenge of managing several thousands of requirements written in natural language. The large number of requirements causes bottlenecks in the requirements management process and calls for increased efficiency in requirements engineering. This thesis presents results from empirical investigations of usi

The "European Guidelines on Quality Criteria for Diagnostic Radiographic Images" do not address the choice of the film characteristic (H&D) curve, which is an important parameter for the description of a radiographic screen–film system. The image contrast of clinical lumbar spine and chest radiographs was altered by digital image processing techniques, simulating images with different H&D